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Showing 1–8 of 8 results
Advanced filters: Author: David G Myszka Clear advanced filters

  • A Staphylococcus aureus leukotoxin targets cells expressing the chemokine receptor CCR5, a mechanism for the specificity of leukotoxins towards different immune cells.

    • Francis Alonzo III
    • Lina Kozhaya
    • Victor J. Torres
    Research
    Nature
    Volume: 493, P: 51-55

  • The signaling adaptor TRAF6 is a ubiquitin E3 ligase whose activity can lead to activation of NF-κB and MAPK pathways. New data based on the structure of TRAF6 in complex with the ubiquitin E2 Ubc13 suggest that other TRAFs do not interact with Ubc13 and that oligomerization of TRAF6 is needed for downstream signal transduction.

    • Qian Yin
    • Su-Chang Lin
    • Hao Wu
    Research
    Nature Structural & Molecular Biology
    Volume: 16, P: 658-666

  • ESCRT-III proteins play important roles in multivesicular body (MVB) formation, cytokinesis, and enveloped virus budding. The structure of Ist1, which also functions in cytokinesis and MVB sorting, reveals that it, too, is an ESCRT-III family member and suggests that this protein family uses a common mode of autoinhibition.

    • Monika Bajorek
    • Heidi L Schubert
    • Wesley I Sundquist
    Research
    Nature Structural & Molecular Biology
    Volume: 16, P: 754-762

  • V-domain immunoglobulin suppressor of T cell activation (VISTA) selectively engages P-selectin glycoprotein ligand-1 (PSGL-1) and suppresses T cells at acidic pH similar to those in tumour microenvironments, thereby mediating resistance to anti-tumour immune responses.

    • Robert J. Johnston
    • Linhui Julie Su
    • Alan J. Korman
    Research
    Nature
    Volume: 574, P: 565-570

  • Ptacin et al. utilize a semi-synthetic microbial platform with an expanded genetic code to discover a PEGylated IL-2 compound that stimulates Tregs, with minimal effects on effector populations. Studies in mice and primates demonstrate Treg stimulation and support development of this compound for the potential treatment of autoimmune diseases.

    • Jerod L. Ptacin
    • Lina Ma
    • Marcos E. Milla
    ResearchOpen Access
    Communications Medicine
    Volume: 4, P: 1-16