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Showing 1–11 of 11 results
Advanced filters: Author: David G. Ashbrook Clear advanced filters

  • A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

    • Erola Pairo-Castineira
    • Sara Clohisey
    • J. Kenneth Baillie
    Research
    Nature
    Volume: 591, P: 92-98

  • The authors defined a roadmap for investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders. Their proof-of-concept study using the largest available common variant data sets for schizophrenia and volumes of several (mainly subcortical) brain structures did not find evidence of genetic overlap.

    • Barbara Franke
    • Jason L Stein
    • Patrick F Sullivan
    Research
    Nature Neuroscience
    Volume: 19, P: 420-431

  • Dimethyl fumarate (DMF) is an anti-inflammatory drug proposed as a treatment for COVID19. Here the results are reported from a randomised trial testing DMF treatment in 713 patients hospitalised with COVID-19. DMF was not associated with any improvement in day 5 outcomes.

    • Peter Sandercock
    • Janet Darbyshire
    • Martin J. Landray
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Small modifications to the organic linkers in metal–organic framework materials (MOFs) can profoundly change their properties. Now, selective in situ esterification of a carboxylic-acid-based linker leads to a MOF with two types of channel having different surface chemistries. Adsorption into these channels is independent and can be switched using thermal or chemical triggers.

    • M. Infas H. Mohideen
    • Bo Xiao
    • Russell E. Morris
    Research
    Nature Chemistry
    Volume: 3, P: 304-310

  • PGGB is a modular framework for efficiently building unbiased pangenome graphs, supporting diverse downstream analyses.

    • Erik Garrison
    • Andrea Guarracino
    • Pjotr Prins
    Research
    Nature Methods
    Volume: 21, P: 2008-2012

  • The assembly–disassembly–organization–reassembly (ADOR) process has recently enabled the synthesis of unusual — and sometimes previously inaccessible — inorganic materials. Further insight into its complex mechanism has now been gained that explains the unexpected formation and structure of such a zeolite.

    • Samuel A. Morris
    • Giulia P. M. Bignami
    • Sharon E. Ashbrook
    Research
    Nature Chemistry
    Volume: 9, P: 1012-1018

  • The promise shown by metal–organic frameworks for various applications is somewhat dampened by their instability towards water. Now, an activated MOF has shown good hydrolytic stability owing to the presence of weak, sacrificial coordination bonds that act as a ‘crumple zone’. On hydration, these weak bonds are cleaved preferentially to stronger coordination bonds that hold the MOF together.

    • Lauren N. McHugh
    • Matthew J. McPherson
    • Russell E. Morris
    Research
    Nature Chemistry
    Volume: 10, P: 1096-1102

  • Genome-wide association studies are used to identify common genetic variants that affect the structure of selected subcortical regions of the human brain; their identification provides insight into the causes of variability in brain development and may help to determine mechanisms of neuropsychiatric dysfunction.

    • Derrek P. Hibar
    • Jason L. Stein
    • Sarah E. Medland
    Research
    Nature
    Volume: 520, P: 224-229