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The pH dependence of the activity of Escherichia colimain sodium-proton antiporter NhaA is still not fully understood. Here, the authors use continuous constant pH molecular dynamics simulations to identify NhaA proton carrier residues and elucidate its gating and ion transport processes.

Driving a quantum material from trivial to non-trivial topological phase can be engineered, for instance, by an applied external field but understanding the physics of the transition can be complex. Here, the authors report a pressure-induced topological phase transition from a semiconductor to a Weyl semimetal phase in 2D Te, and investigate the underlying dynamics using a range of magneto-transport techniques.

A scalable mass cytometry-based method for morphometrically classifying hematopoietic cells demonstrates diagnostic utility when applied to clinical samples.

Sydnor et al. developed a new tractography atlas of thalamocortical structural connections and applied it to three youth samples. They uncovered coordinated development between thalamic connectivity and hierarchical cortical plasticity in humans.

Ultra-narrow quantum Hall Josephson junctions defined in encapsulated graphene nanoribbons exhibit a chiral supercurrent, visible up to 8  T.

Electrophiles activate the transient receptor potential ion channel TRPA1 by a two-step cysteine modification mechanism, which stabilizes a cytoplasmic loop that controls gating and calcium permeability.

Spin and charge dynamics are inevitably linked, the study of the one often illuminating the other. Here, the authors study spin relaxation in ambipolar polymers and, backed by simulations, show how charge dynamics and wavefunction localization together set relaxation times up to room temperature.

Fe3GaTe2 is a van der Waals material with a Curie temperature well above room temperature, making it an attractive material for integration into spintronic devices. Here, Kajale et al demonstrate spin-orbit torque induced switching of the magnetization of Fe3GaTe2, above room temperature, using a Pt spin Hall layer.

Qudits, higher-dimensional analogues of qubits, expand quantum state space for information processing using fewer physical units. Here the authors demonstrate control over a 16-dimensional Hilbert space, equivalent to four qubits, using combined electron-nuclear states of a single Sb donor atom in Si.

Exotic states emerge from the interplay between band topology and ferromagnetism, but it remains less known in canted-antiferromagnetic phase. Here, the authors realize a canted-antiferromagnetic Chern insulator in atomically-thin MnBi₂Te₄ with electrical control of chiral-edge state transport.

Low-cost point-of-care sensors are vital for precision medicine. Here, the authors have repurposed a glucometer for breast cancer therapeutic detection capable of sensing tamoxifen in human blood, utilizing blood glucose to power and amplify the therapeutic signals

Roy-Chowdhury et al. report structures of the human leak channel K_2P13.1 that identify a hydrophilic pore restriction and a polyunsaturated-fatty-acid-binding site corresponding to a small-molecule agonist site in the K_2P family.

Glycine receptors (GlyR) are a critical postsynaptic component of spinal neurons. Here, the auhtors present cryo-EM structures of a heteromeric GlyR in the presence of an antagonist, agonist and agonist with a positive allosteric modulator.

Sodium-dependent glucose transporters (SGLTs) transport sugars across the plasma membrane and play important roles in renal sugar reabsorption. Here authors develop structural models of human SGLT1/2 (hSGLT1/2) in complex with inhibitors which helps to understand inhibitor subtype selectivity.

GPCR dynamics are critical for signal transmission into the cell. Here, the authors probe receptor plasticity using molecular dynamics simulations, enabling the detection of allosteric sites and drug entry gateways for a broad range of GPCR types.

Antigen-restricted mature T cells can be generated from pluripotent stem cells edited to lack endogenous T cell receptors and class I major histocompatibility complexes by introducing the T cell selection components into the stromal microenvironment.

When high-harmonic emission from a ZnO crystal is perturbed with a bright squeezed vacuum beam, a comb of super-bunched high-order sidebands is created. This indicates photon bunching and the generation of a non-coherent state at the short wavelength.

SPNS2 exports S1P and FTY720-P to control immune cell migration. Here, the authors use cryo-EM, immunofluorescence, in vitro binding and in vivo S1P export, and MD simulations to uncover the mechanisms of SPNS2’s transport and inhibition.

The folding of outer membrane proteins (OMPs) is catalyzed by the βbarrel assembly machinery (BAM). Here, structural and functional analyses of BAM stabilized in distinct conformations elucidate the roles of lateral gate opening and interactions of BAM with the lipid bilayer in OMP assembly.

Free-electron laser pulses generated from self-amplification of spontaneous emission scheme vary from one another in their characteristics. Here the authors demonstrate a transient absorption spectroscopy method to characterize the frequency chirp of the FEL pulses.

The role of the dielectric environment in thermally activated delayed fluorescence (TADF) is not yet fully understood. Here the authors reveal the relevance of environment–emitter interactions in gating the reverse intersystem crossing and its particular relevance in dipolar TADF emitters.

High-fidelity deterministic quantum state transfer and multi-qubit entanglement are demonstrated in a quantum network comprising two superconducting quantum nodes one metre apart, with each node including three interconnected qubits.

Hot carriers dominate energy transport across graphene p–n junctions that are excited by ultrafast laser pulses, and set fundamental limits on device speeds.

A semiconductor chip, coupled to an ion-sensitive field effect transistor (ISFET) pH sensor, can amplify and quantitate DNA in real time without dyes, cameras and external heating devices.

Quantized conductance in the transport of neutral atoms is observed in an optically produced channel — either a quantum point contact or a quantum wire — between two atom reservoirs; the lowest non-zero conductance value is the universal conductance quantum, the reciprocal of Planck’s constant.

It is often assumed that systems that can be analyzed accurately via mean-field theory would not be worth looking at using quantum algorithms, given entanglement plays no key role. Here, the authors show instead that a quantum advantage can be expected for simulating the exact time evolution of such electronic systems.

Mouse models of severe congenital neutropenia using patient-derived mutations in the GFI1 locus are used to determine the mechanisms by which the disease progresses.

KUP transporters facilitate potassium uptake by the co-transport of protons and are key players in potassium homeostasis. Here authors identify the potassium importer KimA from Bacillus subtilis as a new member of the KUP transporter family and show the cryo-EM structure of KimA in an inward-occluded, trans-inhibited conformation.

Control of CRISPR-Cas9 activity allows for fine-tuning of editing and gene expression. Here the authors use gRNAs modified with RNA aptamers to enable small molecule control in bacterial systems.

The thymus is sensitive to acute insults including infection, as well as to injury from chemotherapy and myeloablative conditioning before hematopoietic cell transplantation. Here, Granadier et al. describe a role for IL-18 in limiting thymic regeneration by stimulating NK cells, which then target thymic epithelial cells.

The simulation of quantum dynamics is a challenging task to solve with classical resources. An experiment with a trapped-ion quantum processor now shows the efficient simulation of the evolution of large-scale many-body quantum systems.

Gene regulatory network architecture and complex dosage effects from paralogue diversification converge to shape phenotypic space, producing the potential for both strongly buffered phenotypes and sudden bursts of phenotypic change.

Here, the authors show robust edge state transport in patterned nanoribbon networks produced on epigraphene—graphene that is epitaxially grown on non-polar faces of SiC wafers. The edge state forms a zero-energy, one-dimensional ballistic network with dissipationless nodes at ribbon–ribbon junctions.

A simple programmable quantum processor has been created using trapped atomic ions. The system can be programmed with 15 classical inputs to produce any unitary operation on two qubits. This trapped-ion approach is amenable to scaling up for creating more complex circuits.

The 26S proteasome contains a hexamer of ATPase subunits, which binds, unfolds and translocates substrates in an ATP-dependent manner. Kim et al. use FRET to show that ATP binding preferentially occurs at neighbouring subunits of the hexamer, and identify two allosteric systems that coordinate translocation.

By determining the crystal structure of the Na + /H + antiporter NhaA at active pH, the authors show how substrate accessibility to the ion-binding site can be controlled by pH sensitive switch located on the cytoplasmic surface.

There is growing interest in non-traditional materials for logic applications. Here, the authors demonstrate a domain device architecture based on ferroelectric LiNbO₃ crystals with gate voltage controlled transistor without subthreshold swing and source voltage controlled nonvolatile transistor.

The electrical and optical properties of a material depend strongly on the details of its crystal structure. Here, the authors report a technique to mechanically deform the lattice of monolayer graphene with strain, and electrically detect the generation of a scalar potential that modifies the graphene work function.

An optically addressable fluorescent-protein spin qubit is realized using enhanced yellow fluorescent protein; the qubit can be coherently controlled at liquid-nitrogen temperatures and the spin detected at room temperature in cells.

Far-field mid-infrared spectroscopy reveals both the electroluminescence of hyperbolic phonon polaritons of hexagonal boron nitride excited by strongly biased graphene, and the associated radiative energy transfer through the material.

Materials formed by linking metal ions with organic ligands have potential for gas adsorption and storage, and can be flexible in response to stimuli. Now, suitable organic linkers result in a material that undergoes a large structural change, but does not lose crystallinity.

A large nuclear spin has been successfully placed in a Schrödinger cat state, a superposition of its two most widely separated spin coherent states. This can be used as an error-correctable qubit.

Second-order superlattices emerging in magic-angle twisted bilayer graphene aligned with hexagonal boron nitride are visualized in real space through cryogenic nano-imaging, revealing the impact of strain and twist-angle variations.

Polaritons are confined hybrid light-matter excitations holding potential for optoelectronic and sensing applications, but their characterization is usually limited to optical spectroscopy. Here, the authors report the electrical spectroscopy of mid-infrared plasmon-phonon polaritons in Au/hBN/graphene nanoresonators, showing high lateral confinement and quality factors.

The intracellular applications of STED microscopy are limited by the availability of dyes. Here the authors develop a two-colour labelling strategy based on SiR and ATTO590 dyes, and apply their strategy to image various subcellular membrane compartments.

MoS₂/hBN/graphene van der Waals heterostructures with a clean interface and optimized barrier height and gate coupling ratio enable the realization of ultrafast non-volatile flash memory.