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Showing 1–3 of 3 results
Advanced filters: Author: David Granadier Clear advanced filters
  • The thymus is sensitive to acute insults including infection, as well as to injury from chemotherapy and myeloablative conditioning before hematopoietic cell transplantation. Here, Granadier et al. describe a role for IL-18 in limiting thymic regeneration by stimulating NK cells, which then target thymic epithelial cells.

    • David Granadier
    • Kirsten Cooper
    • Jarrod A. Dudakov
    ResearchOpen Access
    Nature Immunology
    Volume: 26, P: 1699-1711
  • Here the authors identify age-associated changes in the epithelial cell compartment of the thymus that form high-density nonproductive microenvironmental niches that contribute toward thymic involution and inhibit its repair following injury.

    • Anastasia I. Kousa
    • Lorenz Jahn
    • Jarrod A. Dudakov
    ResearchOpen Access
    Nature Immunology
    Volume: 25, P: 1593-1606
  • This Review discusses recent advances in our understanding of the biology of endogenous tissue regeneration in the thymus, highlighting the clinical implications of poor thymic recovery.

    • David Granadier
    • Dante Acenas II
    • Jarrod A. Dudakov
    Reviews
    Nature Reviews Immunology
    Volume: 25, P: 407-424