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Showing 1–3 of 3 results
Advanced filters: Author: David Heidary Clear advanced filters

  • The cytochrome P450 enzyme CYP1B1 is overexpressed in a variety of tumors, and is correlated with poor treatment outcomes; thus, it is desirable to develop CYP1B1 inhibitors to restore chemotherapy efficacy. Here the authors describe the creation of light-triggered CYP1B1 inhibitors as “prodrugs”, and achieve >6000-fold improvement in potency upon activation with low-energy (660 nm) light.

    • Dmytro Havrylyuk
    • Austin C. Hachey
    • Edith C. Glazer
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10