Nature Search

Immunological adjuvants promote activated T cell survival via induction of Bcl-3

Thomas C. Mitchell
David Hildeman
Philippa Marrack
Research01 May 2001
Nature Immunology

Volume: 2, P: 397-402
Publisher Correction: The immune cell landscape in kidneys of patients with lupus nephritis

Arnon Arazi
Deepak A. Rao
Daniel H. Goldman
Amendments and Corrections13 Aug 2019
Nature Immunology

Volume: 20, P: 1404
The immune cell landscape in kidneys of patients with lupus nephritis

Much about the kidney-resident immune populations is a black box. Hacohen and colleagues use single cell RNA sequencing of kidney, skin and urine from lupus nephritis patients to describe the transcriptional state of the immune cells present in each compartment.

Arnon Arazi
Deepak A. Rao
Daniel H. Goldman
Research17 Jun 2019
Nature Immunology

Volume: 20, P: 902-914
RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development

Yi Gu
Hee-Don Chae
David A Williams
Research08 Oct 2006
Nature Immunology

Volume: 7, P: 1182-1190
Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Ellie Giles
Amendments and CorrectionsOpen Access16 Sept 2024
Scientific Reports

Volume: 14, P: 1-2
Bone marrow plasma cells require P2RX4 to sense extracellular ATP

We demonstrate the role of the ligand-gated purinergic ion channel P2RX4 in maintaining mouse plasma cells in their bone marrow niche.

Masaki Ishikawa
Zainul S. Hasanali
Avinash Bhandoola
Research14 Feb 2024
Nature

Volume: 626, P: 1102-1107
Gimap5-dependent inactivation of GSK3β is required for CD4⁺ T cell homeostasis and prevention of immune pathology

Loss of function GIMAP5 mutation is associated with lymphopenia, but how it mediates T cell homeostasis is unclear. Here the authors study Gimap5^−/− mice and a patient with GIMAP5 deficiency to show how this GTPAse negatively regulates GSK3β activity to prevent DNA damage and cell death.

Andrew R. Patterson
Mehari Endale
Kasper Hoebe
ResearchOpen Access30 Jan 2018
Nature Communications

Volume: 9, P: 1-15
Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes

Single-cell transcriptomic and proteomic data from synovial tissue from individuals with rheumatoid arthritis classify patients into groups based on abundance of cell states that can provide insights into pathology and predict individual treatment responses.

Fan Zhang
Anna Helena Jonsson
Soumya Raychaudhuri
ResearchOpen Access08 Nov 2023
Nature

Volume: 623, P: 616-624
Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells

The signals controlling T_reg cell homeostasis and survival are still being determined. Liston and colleagues demonstrate that peripheral T_reg cells depend critically on IL-2 and the survival factor Mcl-1 but not on Bcl-2.

Wim Pierson
Bénédicte Cauwe
Adrian Liston
Research14 Jul 2013
Nature Immunology

Volume: 14, P: 959-965
IFN-γ and self-absorbed CD4⁺ T cells: a regulatory double negative

Interferon-γ exerts many effects on the immune system. A new report shows that it induces both autophagy and Irgm1, a GTPase that protects activated CD4⁺ T cells from executing autophagy.

David Hildeman
Edith Janssen
News & Views01 Nov 2008
Nature Immunology

Volume: 9, P: 1210-1212
Naturally-aged microglia exhibit phagocytic dysfunction accompanied by gene expression changes reflective of underlying neurologic disease

Alyssa L. Thomas
Maria A. Lehn
Claire A. Chougnet
ResearchOpen Access14 Nov 2022
Scientific Reports

Volume: 12, P: 1-10
Author Correction: Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways

Evan Der
Hemant Suryawanshi
Fan Zhang
Amendments and Corrections11 Oct 2019
Nature Immunology

Volume: 20, P: 1556
T-cell receptor signal strength and epigenetic control of Bim predict memory CD8⁺ T-cell fate

Kun-Po Li
Brian H. Ladle
David A. Hildeman
ResearchOpen Access26 Sept 2019
Cell Death & Differentiation

Volume: 27, P: 1214-1224
Gucy1α1 specifically marks kidney, heart, lung and liver fibroblasts

Valeria Rudman-Melnick
Davy Vanhoutte
Prasad Devarajan
ResearchOpen Access26 Nov 2024
Scientific Reports

Volume: 14, P: 1-16
AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Abraham Heifets
ResearchOpen Access02 Apr 2024
Scientific Reports

Volume: 14, P: 1-16
Homeostasis of αβ TCR⁺ T cells

Philippa Marrack
Jeremy Bender
John Kappler
Reviews01 Aug 2000
Nature Immunology

Volume: 1, P: 107-111
Bim controls IL-15 availability and limits engagement of multiple BH3-only proteins

S Kurtulus
A Sholl
D A Hildeman
Research15 Aug 2014
Cell Death & Differentiation

Volume: 22, P: 174-184
Mcl-1 antagonizes Bax/Bak to promote effector CD4⁺ and CD8⁺ T-cell responses

P Tripathi
B Koss
D A Hildeman
Research05 Apr 2013
Cell Death & Differentiation

Volume: 20, P: 998-1007
Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways

Nephritis is a major cause of lupus morbidity. Putterman and colleagues use single-cell RNA sequencing on human renal and skin biopsies to describe the expression landscape associated with lupus nephritis.

Evan Der
Hemant Suryawanshi
Fan Zhang
Research20 May 2019
Nature Immunology

Volume: 20, P: 915-927
The Bcl2a1 gene cluster finally knocked out: first clues to understanding the enigmatic role of the Bcl-2 protein A1

Ingolf Berberich
David A Hildeman
NewsOpen Access24 Mar 2017
Cell Death & Differentiation

Volume: 24, P: 572-574
Aging mitigates the severity of obesity-associated metabolic sequelae in a gender independent manner

Maria E. Moreno-Fernandez
Vishakha Sharma
Senad Divanovic
ResearchOpen Access07 Jun 2021
Nutrition & Diabetes

Volume: 11, P: 1-13
The Bcl-2 family: roles in cell survival and oncogenesis

Suzanne Cory
David C S Huang
Jerry M Adams
Reviews24 Nov 2003
Oncogene

Volume: 22, P: 8590-8607
Apoptotic cell death in disease—Current understanding of the NCCD 2023

Ilio Vitale
Federico Pietrocola
Lorenzo Galluzzi
Reviews26 Apr 2023
Cell Death & Differentiation

Volume: 30, P: 1097-1154
Self-antigen recognition by TGFβ1-deficient T cells causes their activation and systemic inflammation

Ramireddy Bommireddy
Leena J Pathak
Thomas Doetschman
Research24 Jul 2006
Laboratory Investigation

Volume: 86, P: 1008-1019

Search

Immunological adjuvants promote activated T cell survival via induction of Bcl-3

Publisher Correction: The immune cell landscape in kidneys of patients with lupus nephritis

The immune cell landscape in kidneys of patients with lupus nephritis

RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development

Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

Bone marrow plasma cells require P2RX4 to sense extracellular ATP

Gimap5-dependent inactivation of GSK3β is required for CD4⁺ T cell homeostasis and prevention of immune pathology

Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells

IFN-γ and self-absorbed CD4⁺ T cells: a regulatory double negative

Naturally-aged microglia exhibit phagocytic dysfunction accompanied by gene expression changes reflective of underlying neurologic disease

Author Correction: Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways

T-cell receptor signal strength and epigenetic control of Bim predict memory CD8⁺ T-cell fate

Gucy1α1 specifically marks kidney, heart, lung and liver fibroblasts

AI is a viable alternative to high throughput screening: a 318-target study

Homeostasis of αβ TCR⁺ T cells

Bim controls IL-15 availability and limits engagement of multiple BH3-only proteins

Mcl-1 antagonizes Bax/Bak to promote effector CD4⁺ and CD8⁺ T-cell responses

Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways

The Bcl2a1 gene cluster finally knocked out: first clues to understanding the enigmatic role of the Bcl-2 protein A1

Aging mitigates the severity of obesity-associated metabolic sequelae in a gender independent manner

The Bcl-2 family: roles in cell survival and oncogenesis

Apoptotic cell death in disease—Current understanding of the NCCD 2023

Self-antigen recognition by TGFβ1-deficient T cells causes their activation and systemic inflammation

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