Nature Search

Natural selection increases female fitness by reversing the exaggeration of a male sexually selected trait

Natural and sexual selection can be in opposition favouring different trait sizes, but disentangling these processes empirically is difficult. Here Okada et al. show that predation on males shifts the balance of selection in experimentally evolving beetle populations, disfavoring a sexually-selected male trait but increasing female fitness.

Kensuke Okada
Masako Katsuki
David J. Hosken
ResearchOpen Access08 Jun 2021
Nature Communications

Volume: 12, P: 1-10
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Control of the Responsiveness of the Blowfly to Water

DAVID R. EVANS
Research17 Jun 1961
Nature

Volume: 190, P: 1132-1133
XBP1 expression in pancreatic islet cells is associated with poor glycaemic control especially in young non-obese onset diabetes across ancestries

Siddiqui et al. explore the role of islet-specific XBP1 expression in type 2 diabetes (T2D) and glycemic traits across diverse ancestries. XBP1 eQTL is associated with T2D, beta-cell function, HbA1c and drug response in East and South Asians in whom this variant is common and beta-cell dysfunction is a significant driver of early onset T2D.

Moneeza K. Siddiqui
Theo Dupuis
Ana Viñuela
ResearchOpen Access24 Sept 2025
Communications Medicine

Volume: 5, P: 1-10
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Genetic architecture of routinely acquired blood tests in a British South Asian cohort

Here, the authors used electronic healthcare records to analyse the genetic basis of variation in 42 routinely-acquired quantitative blood tests among up to 40,000 British South Asian volunteers from the Genes and Health study. By combining their results with genetic findings from UK Biobank, they explore similarities and differences between ancestries in the genetic basis of these traits.

Benjamin M. Jacobs
Daniel Stow
David A. van Heel
ResearchOpen Access16 Oct 2024
Nature Communications

Volume: 15, P: 1-12
Conjugated Phenols in the Fusarium Wilt Syndrome

DAVID DAVIS
P. E. WAGGONER
A. E. DIMOND
Research21 Nov 1953
Nature

Volume: 172, P: 959-961
X-ray absorption spectroscopy

C. David Garner
News & Views01 Jan 1979
Nature

Volume: 277, P: 89-90
Matrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic liver

Structural changes mediated by advanced glycation end-products enhance extracellular matrix viscoelasticity, and that viscoelasticity can promote cancer progression in vivo, independent of stiffness.

Weiguo Fan
Kolade Adebowale
Natalie J. Török
ResearchOpen Access31 Jan 2024
Nature

Volume: 626, P: 635-642
X-ray images of supernova remnants

David J. Helfand
News & Views15 May 1980
Nature

Volume: 285, P: 133-134
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Designing a practical high-fidelity long-time quantum memory

Future quantum computers need quantum memories that store arbitrary states for long periods, without incurring significant access latencies. Using high-order dynamical decoupling sequences, this work shows a practical scheme to suppress physical errors and guarantee high-fidelity storage for long times.

Kaveh Khodjasteh
Jarrah Sastrawan
Lorenza Viola
Research19 Jun 2013
Nature Communications

Volume: 4, P: 1-8
Site-directed mutagenesis reveals role of mobile arginine residue in lactate dehydrogenase catalysis

Anthony R. Clarke
Dale B. Wigley
J. John Holbrook
Research18 Dec 1986
Nature

Volume: 324, P: 699-702
Gramicidin forms multi-state rectifying channels

David Busath
Gabor Szabo
Research26 Nov 1981
Nature

Volume: 294, P: 371-373
Multispecific antibodies

David S. Secher
News & Views25 Aug 1977
Nature

Volume: 268, P: 689-690
Spinning comets and planets

David W. Hughes
News & Views11 May 1978
Nature

Volume: 273, P: 100-101
SARS-CoV-2 evolution during treatment of chronic infection

Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Research05 Feb 2021
Nature

Volume: 592, P: 277-282
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Research11 Mar 2021
Nature

Volume: 593, P: 136-141
Family of disulphide-linked dimers containing the ζ and η chains of the T-cell receptor and the γ chain of Fc receptors

David G. Orloff
Chisei Ra
Jean-Pierre Kinet
Research13 Sept 1990
Nature

Volume: 347, P: 189-191
The DNA sequence of the human X chromosome

Mark T. Ross
Darren V. Grafham
David R. Bentley
Research17 Mar 2005
Nature

Volume: 434, P: 325-337
Whole-genome sequencing of a sporadic primary immunodeficiency cohort

Whole-genome sequencing analysis of individuals with primary immunodeficiency identifies new candidate disease-associated genes and shows how the interplay between genetic variants can explain the variable penetrance and complexity of the disease.

James E. D. Thaventhiran
Hana Lango Allen
Kenneth G. C. Smith
Research06 May 2020
Nature

Volume: 583, P: 90-95
Molecular genetic approaches to the analysis of human ophthalmic disease

David N Cooper
Marcelle Jay
Barrie Jay
Research01 Nov 1987
Eye

Volume: 1, P: 699-721
Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Chris Varghese
Luke Peters
Caroline Reinke
ResearchOpen Access26 Aug 2025
npj Digital Medicine

Volume: 8, P: 1-16
Colocalization of retrovirus and target cells on specific fibronectin fragments increases genetic transduction of mammalian cells

Helmut Hanenberg
Xiang Li Xiao
David A. Williams
Research01 Aug 1996
Nature Medicine

Volume: 2, P: 876-882
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

COVID-19 can be associated with neurological complications. Here the authors show that markers of brain injury, but not immune markers, are elevated in the blood of patients with COVID-19 both early and months after SARS-CoV-2 infection, particularly in those with brain dysfunction or neurological diagnoses.

Benedict D. Michael
Cordelia Dunai
David K. Menon
ResearchOpen Access22 Dec 2023
Nature Communications

Volume: 14, P: 1-15
Quantifying Nearshore Sea Turtle Densities: Applications of Unmanned Aerial Systems for Population Assessments

Seth T. Sykora-Bodie
Vanessa Bezy
Kenneth J. Lohmann
ResearchOpen Access18 Dec 2017
Scientific Reports

Volume: 7, P: 1-7
Adeno-associated virus 2 infection in children with non-A–E hepatitis

A case–control study investigating the causes of recent cases of acute hepatitis of unknown aetiology in 32 children identifies an association between adeno-associated virus infection and host genetics in disease susceptibility.

Antonia Ho
Richard Orton
Emma C. Thomson
Research30 Mar 2023
Nature

Volume: 617, P: 555-563
β-Adrenoceptor agonists increase membrane K⁺ conductance in cardiac Purkinje fibres

David C. Gadsby
Research15 Dec 1983
Nature

Volume: 306, P: 691-693
Genetic basis of early onset and progression of type 2 diabetes in South Asians

In a cohort of 50,556 South Asian individuals, partitioned polygenic scores helped identify genetic susceptibility to insulin deficiency and unfavorable fat distribution as key drivers of young-onset T2D diagnosis and faster progression to diabetes-related complications.

Sam Hodgson
Alice Williamson
Sarah Finer
ResearchOpen Access26 Nov 2024
Nature Medicine

Volume: 31, P: 323-331
Dwarfism in an adolescent from the Italian late Upper Palaeolithic

David W. Frayer
William A. Horton
Margherita Mussi
Research05 Nov 1987
Nature

Volume: 330, P: 60-62
Effects of density on monospecific stands of marine algae

David R. Schiel
J. H. Choat
Research29 May 1980
Nature

Volume: 285, P: 324-326
RNA bulges and the helical periodicity of double-stranded RNA

Anamitra Bhattacharyya
Alastair I. H. Murchie
David M. J. Lilley
Research01 Feb 1990
Nature

Volume: 343, P: 484-487
Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

Paul Pharoah and colleagues report the results of a large genome-wide association study of ovarian cancer. They identify new susceptibility loci for different epithelial ovarian cancer histotypes and use integrated analyses of genes and regulatory features at each locus to predict candidate susceptibility genes, including OBFC1.

Catherine M Phelan
Karoline B Kuchenbaecker
Paul D P Pharoah
Research27 Mar 2017
Nature Genetics

Volume: 49, P: 680-691
Genetic mechanisms of critical illness in COVID-19

A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

Erola Pairo-Castineira
Sara Clohisey
J. Kenneth Baillie
Research11 Dec 2020
Nature

Volume: 591, P: 92-98
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
Life history and population regulation shape demographic competence and influence the maintenance of endemic disease

The authors introduce the term demographic competence to describe the ability of a host population to maintain endemic infections, and use models to explore the interaction between population regulation and host–pathogen life history traits.

Matthew J. Silk
David J. Hodgson
Research09 Nov 2020
Nature Ecology & Evolution

Volume: 5, P: 82-91
Cell type-specific responses of human cells to inhibition of replication licensing

S Shreeram
Alison Sparks
J Julian Blow
Research23 Sept 2002
Oncogene

Volume: 21, P: 6624-6632
Extreme temporal homogeneity of helium isotopes at Piton de la Fournaise, Réunion Island

David Graham
John Lupton
Michel Condomines
Research01 Oct 1990
Nature

Volume: 347, P: 545-548
Latitudinal gradient of atmospheric CO₂ due to seasonal exchange with land biota

A. Scott Denning
Inez Y. Fung
David Randall
Research20 Jul 1995
Nature

Volume: 376, P: 240-243
Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis

Akseli Hemminki
Ian Tomlinson
Lauri A. Aaltonen
Research01 Jan 1997
Nature Genetics

Volume: 15, P: 87-90
Genomic investigations of unexplained acute hepatitis in children

An investigation using various methods reports an association between adeno-associated virus 2 and paediatric hepatitis of unknown aetiology.

Sofia Morfopoulou
Sarah Buddle
Judith Breuer
ResearchOpen Access30 Mar 2023
Nature

Volume: 617, P: 564-573
Two contiguous conformations in a nucleic acid duplex

ERIK SELSING
ROBERT D. WELLS
DAVID R. KEARNS
Research21 Sept 1978
Nature

Volume: 275, P: 249-250
Sensory input, sex and function shape hypothalamic cell type development

Paired transcriptomic and chromatin accessibility profiling are used to examine the developmental trajectories of neuronal populations in the hypothalamic preoptic region, including cell types with key roles in physiological and social behaviour functions have been identified.

Harris S. Kaplan
Brandon L. Logeman
Catherine Dulac
ResearchOpen Access05 Mar 2025
Nature

P: 1-12
High SARS-CoV-2 incidence and asymptomatic fraction during Delta and Omicron BA.1 waves in The Gambia

Many low- and middle-income countries, including The Gambia, had low COVID-19 vaccination coverage during the emergence of the Delta and Omicron variants. Here, the authors perform a prospective household cohort study in the Gambia to investigate the dynamics of SARS-Cov-2 infection in this setting.

Sheikh Jarju
Rhys D. Wenlock
Thushan I. de Silva
ResearchOpen Access07 May 2024
Nature Communications

Volume: 15, P: 1-10
Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

Roger Milne and colleagues conduct a genome-wide association study for estrogen receptor (ER)-negative breast cancer combined with BRCA1 mutation carriers in a large cohort. They identify ten new risk variants and find high genetic correlation between breast cancer risk for BRCA1 mutation carriers and risk of ER-negative breast cancer in the general population.

Roger L Milne
Karoline B Kuchenbaecker
Jacques Simard
Research23 Oct 2017
Nature Genetics

Volume: 49, P: 1767-1778
The surface windfield over the Antarctic ice sheets

Thomas R Parish
David H. Bromwich
Amendments and Corrections20 Aug 1987
Nature

Volume: 328, P: 742
Electrogenic glutamate uptake is a major current carrier in the membrane of axolotl retinal glial cells

Helen Brew
David Attwell
Amendments and Corrections20 Aug 1987
Nature

Volume: 328, P: 742
Thiolate gates superoxo states

Formylglycine residues are important functional handles on native and synthetic proteins. The formation of these residues is mediated by a copper enzyme operating via a superoxo intermediate.

David Schilter
Research Highlights18 Mar 2019
Nature Reviews Chemistry

Volume: 3, P: 203
The health effects associated with physical, sexual and psychological gender-based violence against men and women: a Burden of Proof study

Gender-based violence is widespread, affecting women and men worldwide. Stein et al. use a meta-analysis and the Burden of Proof methodology to evaluate associations between gender-based violence and eight health outcomes, including major depressive disorder, substance use and reproductive health.

Caroline Stein
Luisa S. Flor
Emmanuela Gakidou
ResearchOpen Access10 Apr 2025
Nature Human Behaviour

Volume: 9, P: 1201-1216

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