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Showing 1–4 of 4 results
Advanced filters: Author: David Houldershaw Clear advanced filters

  • Understanding the structural basis for the inhibition of archaeal eukaryotic-like RNA polymerases (RNAPs) during virus infection is of interest for drug design. Here, the authors present the cryo-EM structures of apo Sulfolobus acidocaldarius RNAP and the RNAP complex structures with two regulatory factors, RIP and TFS4 that inhibit transcription and discuss their inhibitory mechanisms.

    • Simona Pilotto
    • Thomas Fouqueau
    • Finn Werner
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • A membrane-embedded complex (called T4CC) is essential for injection of Legionella pneumophila effector proteins into human macrophages via a Type IV secretion system. Here, the authors purify and study the T4CC using functional and cryo-EM structural analyses, providing insights into the secretion mechanisms.

    • Amit Meir
    • Kevin Macé
    • Gabriel Waksman
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Cryo-electron microscopy structures of a 2.8 megadalton bacterial type IV secretion system encoded by the plasmid R388 and comprising 92 polypeptides provide insights into the stepwise mechanism of pilus assembly.

    • Kévin Macé
    • Abhinav K. Vadakkepat
    • Gabriel Waksman
    ResearchOpen Access
    Nature
    Volume: 607, P: 191-196