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Advanced filters: Author: David J Schwalb Clear advanced filters

Natural products reveal cancer cell dependence on oxysterol-binding proteins

The identification of cellular targets for natural products that potently inhibit the growth of cancer cell lines implicates oxysterol-binding proteins in the growth of cancer cells. These natural products, termed ORPphilins, also affect sphingomyelin biosynthesis.

Anthony W G Burgett
Thomas B Poulsen
Matthew D Shair
Research07 Aug 2011
Nature Chemical Biology

Volume: 7, P: 639-647
Revision rates of the AMS 800 artificial urinary sphincter: how it stacks up against other implants placed in men

Steven K. Wilson
John J. Mulcahy
M. David Schwalb
Reviews01 Aug 2025
International Journal of Impotence Research

P: 1-2
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

Murphy and colleagues generate an inhibitor of the lipid kinase VPS34, which they use to uncover autophagy substrates. One of their targets, NCOA4, regulates iron homeostasis by binding ferritin heavy chain-1 and targeting ferritin to autolysosomes.

William E. Dowdle
Beat Nyfeler
Leon O. Murphy
Research19 Oct 2014
Nature Cell Biology

Volume: 16, P: 1069-1079

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Natural products reveal cancer cell dependence on oxysterol-binding proteins

Revision rates of the AMS 800 artificial urinary sphincter: how it stacks up against other implants placed in men

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

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