Chromosomal instability (CIN) is a hallmark of many tumours and correlates with the presence of extra centrosomes, but a direct mechanistic link between CIN and extra centrosomes has not been established. Live-cell imaging is now used to demonstrate that extra centrosomes can promote chromosome missegregation as a consequence of cells passing through a transient 'multipolar spindle intermediate'.
- Neil J. Ganem
- Susana A. Godinho
- David Pellman
