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Showing 1–7 of 7 results
Advanced filters: Author: David J. Parras Clear advanced filters

  • The dynamics of antimicrobial resistance gene transfer remain unclear. Here, by integrating bacterial genome and metagenome data with machine learning the authors show that genetic incompatibility is a main limiting factor, while co-occurrence of bacteria in the human microbiome and wastewater contributes to gene transfer.

    • David Lund
    • Marcos Parras-Moltó
    • Erik Kristiansson
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • In this study, He et al. find that the CHARGE syndrome–related chromatin remodeler Chd7 regulates the initiation of myelination and remyelination in the CNS. Chd7 interacts with Sox10 to orchestrate the transcriptional state of myelinogenic genes and serves as a molecular nexus of the regulatory networks that contribute to white matter pathogenesis in CHARGE syndrome.

    • Danyang He
    • Corentine Marie
    • Q Richard Lu
    Research
    Nature Neuroscience
    Volume: 19, P: 678-689

  • Type 1 diabetes mellitus (T1DM) is characterized by beta cell loss because of an autoimmune attack. Here the authors show that an agonist for LRH-1/NR5A2, a nuclear receptor known to be protective against beta cell apoptosis, inhibits immune-mediated inflammation and hyperglycemia in T1DM mouse models.

    • Nadia Cobo-Vuilleumier
    • Petra I. Lorenzo
    • Benoit R. Gauthier
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15

  • Rats can detect frequency deviant tones in a context-dependent manner, indicating a memory-based adaptation in auditory neurons that is shaped by stimuli saliency and behavioral relevance.

    • Laura Quintela-Vega
    • Camilo J. Morado-Díaz
    • Manuel S. Malmierca
    ResearchOpen Access
    Communications Biology
    Volume: 6, P: 1-15