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Showing 1–2 of 2 results
Advanced filters: Author: David Kachaner Clear advanced filters

  • Cancer cell motility is necessary for cell invasion and metastasis. Here, the authors identify CNK2 as a key mediator of cancer cell motility, linking extracellular stimuli via AXL signalling and downstream activation of ARF6 GTPase, resulting in increased metastasis in preclinical models.

    • Guillaume Serwe
    • David Kachaner
    • Marc Therrien
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-21

  • Drosophila Polo kinase is the founding member of the Polo-Like Kinase (PLK) family and a master regulator of mitosis and cytokinesis. Here the authors uncover a molecular mechanism for the spatiotemporal regulation of Polo kinase during mitotic entry through a phosphorylation event that triggers nuclear import.

    • David Kachaner
    • Damien Garrido
    • Vincent Archambault
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16