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Showing 1–17 of 17 results
Advanced filters: Author: David Meierhofer Clear advanced filters

  • Targeting a non-natural micropeptide ‘killswitch’ to several biomolecular condensates altered condensate compositions and revealed condensate functions in human cells

    • Yaotian Zhang
    • Ida Stöppelkamp
    • Denes Hnisz
    ResearchOpen Access
    Nature
    Volume: 643, P: 1107-1116

  • Here the authors demonstrate how protein translation, controlled by Ire1α, regulates neuronal diversification in the developing neocortex.

    • Ekaterina Borisova
    • Andrew G. Newman
    • Mateusz C. Ambrozkiewicz
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-25

  • SAFB proteins protect genome integrity by preventing retrotransposition of L1 elements yet maintaining splicing integrity, via prevention of the exonization of previously integrated transposable elements, a major constituent of human genes.

    • İbrahim Avşar Ilık
    • Petar Glažar
    • Tuğçe Aktaş
    ResearchOpen Access
    Nature
    Volume: 626, P: 1116-1124

  • RNA-binding proteins are involved in the posttranscriptional regulation of a large number of cellular processes and several recent studies have sought to describe the extent of the RNA-binding proteome. Here, Conrad et al. describe serIC, a stringent approach they apply towards defining the RNA-binding proteome of the mammalian nucleus.

    • Thomas Conrad
    • Anne-Susann Albrecht
    • Ulf Andersson Ørom
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11

  • van der Weijden et al. perform genomic, proteomic and metabolic analyses and find that FOXO1-mediated fatty acid oxidation maintains mouse embryos in diapause.

    • Vera A. van der Weijden
    • Maximilian Stötzel
    • Aydan Bulut-Karslioglu
    ResearchOpen Access
    Nature Cell Biology
    Volume: 26, P: 181-193

  • Transcription factors are rich in intrinsic disorder and therefore hard to drug. The authors improve an experimental drug for castration-resistant prostate cancer by learning how the activation domain of the androgen receptor activates transcription.

    • Shaon Basu
    • Paula Martínez-Cristóbal
    • Xavier Salvatella
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 30, P: 1958-1969

  • The authors report that acetylation of cytochrome c on K39 acts as a molecular switch in ischemic skeletal muscle, but not other tissues, to increase respiration and prevent apoptosis. This gives skeletal muscle robust resilience to ischemia and ischemia-reperfusion injury.

    • Paul T. Morse
    • Gonzalo Pérez-Mejías
    • Maik Hüttemann
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • Weigert et al. show that an antagonistic relationship between DNA methyltransferase and Polycomb activity is globally responsible for the maintenance of intermediate methylation levels observed in trophoblast stem cells.

    • Raha Weigert
    • Sara Hetzel
    • Alexander Meissner
    ResearchOpen Access
    Nature Cell Biology
    Volume: 25, P: 579-591

  • TRIM28 depletion in embryonic stem cells disconnects transcriptional condensates from super-enhancers, which is rescued by knockdown of endogenous retroviruses.

    • Vahid Asimi
    • Abhishek Sampath Kumar
    • Denes Hnisz
    ResearchOpen Access
    Nature Genetics
    Volume: 54, P: 1238-1247

  • The canonical DNA methylation maintenance enzyme Dnmt1 displays global de novo methylation activity with greater targeting towards IAP transposons, which may contribute to their stable repression during early development.

    • Chuck Haggerty
    • Helene Kretzmer
    • Alexander Meissner
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 28, P: 594-603

  • In silico models of cells can provide insight into the causes and effects of disease states and reduce the need for in vivo studies. Here, the authors present a kinetic model of hepatocyte metabolism including energy, carbohydrate, lipid and nitrogen metabolism and hormonal and allosteric regulation of enzymatic activity.

    • Nikolaus Berndt
    • Sascha Bulik
    • Hermann-Georg Holzhütter
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • The heterogeneity of colorectal cancer has important clinical and therapeutic implications. Here the authors analysed the responses of a large biobank of organoids and xenografts derived from colorectal patients to a panel of clinically relevant therapeutic agents to identify genes signatures associated with drug response.

    • Moritz Schütte
    • Thomas Risch
    • Marie-Laure Yaspo
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-19

  • Ipatasertib is a potent Akt (protein kinase B) inhibitor synthesized via a chemoenzymatic process. Here, the authors use mutational scanning and algorithm-aided enzyme engineering to optimize a ketoreductase from Sporidiobolus salmonicolor and generate a 10-amino acid substituted variant exhibiting a 64-fold higher kcat and improved yield for the relevant alcohol intermediate, with ≥ 98% conversion and a diastereomeric excess of 99.7% (R,R-trans) from 100 g L−1 ketone after 30 h.

    • Sumire Honda Malca
    • Nadine Duss
    • Rebecca Buller
    ResearchOpen Access
    Communications Chemistry
    Volume: 7, P: 1-11