Nature Search

Brain anatomy of the Cambrian fossil Jianfengia multisegmentalis informs euarthropod phylogeny

Here, the authors present fossilized neural traits from the lower Cambrian euarthropod Jianfengia multisegmentalis, including structured eyestalks and compound eyes, that resolve multiple phylogenetic relationships within Euarthropoda.

Nicholas J. Strausfeld
David R. Andrew
Frank Hirth
ResearchOpen Access28 Aug 2025
Nature Communications

Volume: 16, P: 1-11
The crystal structure of diphtheria toxin

Seunghyon Choe
Melanie J. Bennett
David Eisenberg
Research21 May 1992
Nature

Volume: 357, P: 216-222
Density-dependent network structuring within and across wild animal systems

The number of individuals in a given space influences animal interactions and network dynamics. Here the authors identify general rules underlying density dependence in animal networks and reveal some fundamental differences between spatial and social dynamics.

Gregory F. Albery
Daniel J. Becker
Shweta Bansal
Research04 Sept 2025
Nature Ecology & Evolution

P: 1-12
Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders

The authors analyzed the whole-exome sequences of over 16,000 individuals and found that very rare variants predicted to disrupt the SETD1A gene confer substantial risk for schizophrenia. Damaging variants in SETD1A were also associated with diverse, severe developmental disorders, providing an important genetic link between schizophrenia and other neurodevelopmental disorders.

Tarjinder Singh
Mitja I Kurki
Jeffrey C Barrett
Research14 Mar 2016
Nature Neuroscience

Volume: 19, P: 571-577
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Mapping genomic loci implicates genes and synaptic biology in schizophrenia

A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control individuals identifies common variant associations at 287 genomic loci, and further fine-mapping analyses highlight the importance of genes involved in synaptic processes.

Vassily Trubetskoy
Antonio F. Pardiñas
Jim van Os
Research08 Apr 2022
Nature

Volume: 604, P: 502-508
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
T cell memory response to MPXV infection exhibits greater effector function and migratory potential compared to MVA-BN vaccination

T cell responses can be generated to either pathogen infection or from priming with a vaccine. Here the authors compare T cell generation, phenotype and single cell transcriptome of participants vaccinated with a mpox vaccine or infected with the virus showing that the virus induced T cells showed more effective function and phenotype.

Ji-Li Chen
Beibei Wang
Tao Dong
ResearchOpen Access10 May 2025
Nature Communications

Volume: 16, P: 1-17
Sources of sedimentary lipids deduced from stable carbon-isotope analyses of individual compounds

Gareth Rieley
Robert J. Collier
Anthony E. Fallick
Research01 Aug 1991
Nature

Volume: 352, P: 425-427
Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein

Kevin M. Flaherty
Camilla DeLuca-Flaherty
David B. McKay
Research16 Aug 1990
Nature

Volume: 346, P: 623-628
Magnitude and significance of NAD turnover in human cell line D98/AH2

MARTIN RECHSTEINER
DAVID HILLYARD
BALDOMERO M. OLIVERA
Research26 Feb 1976
Nature

Volume: 259, P: 695-696
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Research11 Mar 2021
Nature

Volume: 593, P: 136-141
SARS-CoV-2 evolution during treatment of chronic infection

Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Research05 Feb 2021
Nature

Volume: 592, P: 277-282
Delayed Mortality in Adult Chickens exposed to 1 Atmosphere Oxygen

HAROLD S. WEISS
DAVID L. BECKMAN
RONALD A. WRIGHT
Research04 Dec 1965
Nature

Volume: 208, P: 1003-1004
XBP1 expression in pancreatic islet cells is associated with poor glycaemic control especially in young non-obese onset diabetes across ancestries

Siddiqui et al. explore the role of islet-specific XBP1 expression in type 2 diabetes (T2D) and glycemic traits across diverse ancestries. XBP1 eQTL is associated with T2D, beta-cell function, HbA1c and drug response in East and South Asians in whom this variant is common and beta-cell dysfunction is a significant driver of early onset T2D.

Moneeza K. Siddiqui
Theo Dupuis
Ana Viñuela
ResearchOpen Access24 Sept 2025
Communications Medicine

Volume: 5, P: 1-10
Harnessing landrace diversity empowers wheat breeding

Genomic and phenomic screens of 827 wheat landraces from the A. E. Watkins collection provide insight into the wheat population genetic background, unlocking many agronomic traits and revealing haplotypes that could potentially be used to improve modern wheat cultivars.

Shifeng Cheng
Cong Feng
Simon Griffiths
ResearchOpen Access17 Jun 2024
Nature

Volume: 632, P: 823-831
Crystal structure of Aplysia ADP ribosyl cyclase, a homologue of the bifunctional ectozyme CD38

G. Sridhar Prasad
Duncan E. McRee
C. David Stout
Research01 Nov 1996
Nature Structural Biology

Volume: 3, P: 957-964
Tensions in science

David Dickson
Books & Arts24 Jul 1986
Nature

Volume: 322, P: 317-318
Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways

Bing Xiao
Stephen J. Smerdon
Steven J. Gamblin
Research13 Jul 1995
Nature

Volume: 376, P: 188-191
Radiolarian and silicoflagellate response to oceanographic changes associated with the 1983 El Niño

Nicklas G. Pisias
David W. Murray
Adrienne K. Roelofs
Research20 Mar 1986
Nature

Volume: 320, P: 259-262
Distinct genetic liability profiles define clinically relevant patient strata across common diseases

Stratified medicine promises to tailor treatment for individual patients, however it remains a major challenge to leverage genetic risk data to aid patient stratification. Here the authors introduce an approach to stratify individuals based on the aggregated impact of their genetic risk factor profiles on tissue-specific gene expression levels, and highlight its ability to identify biologically meaningful and clinically actionable patient subgroups, supporting the notion of different patient ‘biotypes’ characterized by partially distinct disease mechanisms.

Lucia Trastulla
Georgii Dolgalev
Michael J. Ziller
ResearchOpen Access01 Jul 2024
Nature Communications

Volume: 15, P: 1-28
A molecular solution to the riddle of the giant panda's phylogeny

Stephen J. O'Brien
William G. Nash
Raoul E. Benveniste
Research12 Sept 1985
Nature

Volume: 317, P: 140-144
Analgesia induced in vivo by central administration of enkephalin in rat

JAMES D. BELLUZZI
NORMAN GRANT
LARRY STEIN
Research15 Apr 1976
Nature

Volume: 260, P: 625-626
Genetic mechanisms of critical illness in COVID-19

A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

Erola Pairo-Castineira
Sara Clohisey
J. Kenneth Baillie
Research11 Dec 2020
Nature

Volume: 591, P: 92-98
Genetic architecture of routinely acquired blood tests in a British South Asian cohort

Here, the authors used electronic healthcare records to analyse the genetic basis of variation in 42 routinely-acquired quantitative blood tests among up to 40,000 British South Asian volunteers from the Genes and Health study. By combining their results with genetic findings from UK Biobank, they explore similarities and differences between ancestries in the genetic basis of these traits.

Benjamin M. Jacobs
Daniel Stow
David A. van Heel
ResearchOpen Access16 Oct 2024
Nature Communications

Volume: 15, P: 1-12
High–Level Expression of Diphtheria Toxin Peptides in Escherichia coli

Lawrence Greenfield
Harry F. Dovey
David H. Gelfand
Research01 Nov 1986
Bio/Technology

Volume: 4, P: 1006-1011
Complement genes contribute sex-biased vulnerability in diverse disorders

Sexual dimorphism in genetic vulnerability to schizophrenia, systemic lupus erythematosus and Sjögren’s syndrome is linked to differential protein abundance from alleles of complement component 4.

Nolan Kamitaki
Aswin Sekar
Steven A. McCarroll
Research11 May 2020
Nature

Volume: 582, P: 577-581
Crystal structure of an RNA aptamer–protein complex at 2.8 Å resolution

Maire A. Convery
Siân Rowsell
Peter G. Stockley
Research01 Feb 1998
Nature Structural Biology

Volume: 5, P: 133-139
Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

A new GWAS of schizophrenia (11,260 cases and 24,542 controls) and meta-analysis identifies 50 new associated loci and 145 loci in total. The common variant association signal is highly enriched in mutation-intolerant genes and in regions under strong background selection.

Antonio F. Pardiñas
Peter Holmans
James T. R. Walters
Research26 Feb 2018
Nature Genetics

Volume: 50, P: 381-389
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Intra- and inter-individual genetic differences in gene expression

Mark Cowley
Chris Cotsapas
Peter Little
ResearchOpen Access15 Apr 2008
Nature Precedings

P: 1
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

Paul R Burton
David G Clayton
Matthew A Brown
Research21 Oct 2007
Nature Genetics

Volume: 39, P: 1329-1337
Information transmission in remote viewing experiments

DAVID MARKS
RICHARD KAMMANN
Research17 Aug 1978
Nature

Volume: 274, P: 680-681
Astronomy for the amateur

David W. Hughes
Books & Arts07 Dec 1978
Nature

Volume: 276, P: 653-654
Decreased maternal serum acetate and impaired fetal thymic and regulatory T cell development in preeclampsia

Maternal immunological dysregulation might affect the immunological development of the fetus. Here the authors show that decreased maternal acetate is associated with preeclampsia, impaired fetal thymic output and regulatory T cell development.

Mingjing Hu
David Eviston
Ralph Nanan
ResearchOpen Access10 Jul 2019
Nature Communications

Volume: 10, P: 1-13
Mediation of virion penetration into vascular cells by association of basic fibroblast growth factor with herpes simplex virus type 1

Andrew Baird
Robert Z. Florkiewicz
David P. Hajjar
Research22 Nov 1990
Nature

Volume: 348, P: 344-346
Reaction between Molecular Oxygen and Photo-excited Protoporphyrin IX

J. DALTON
C. A. MCAULIFFE
DAVID H. SLATER
Research18 Feb 1972
Nature

Volume: 235, P: 388
Three-dimensional structure of a peptide extending from one end of a class I MHC binding site

Edward J. Collins
David N. Garboczi
Don C. Wiley
Research13 Oct 1994
Nature

Volume: 371, P: 626-629
Selective killing of HIV-infected cells by recombinant human CD4-Pseudomonas exotoxin hybrid protein

Vijay K. Chaudhary
Tamio Mizukami
Edward A. Berger
Research22 Sept 1988
Nature

Volume: 335, P: 369-372
Maternal carriage of Prevotella during pregnancy associates with protection against food allergy in the offspring

Incidence of food allergy in westernized populations is associated with low abundance of Prevotella. Here, the authors analyse the microbiome of a mother-infant prebirth cohort and find that maternal carriage, but not infant carriage, of P. copri during pregnancy predicts the absence of food allergy in the offspring.

Peter J. Vuillermin
Martin O’Hely
Esther Bandala Sanchez
ResearchOpen Access24 Mar 2020
Nature Communications

Volume: 11, P: 1-7
Crystal structure of E.coli RuvA with bound DNA Holliday junction at 6 Å resolution

David Hargreaves
David W. Rice
John B. Rafferty
Research01 Jun 1998
Nature Structural Biology

Volume: 5, P: 441-446
FGF21 is required for protein restriction to extend lifespan and improve metabolic health in male mice

The restriction of dietary protein or amino acid intake is well established to extend lifespan in multiple species. Here, the authors show that the endocrine hormone FGF21 is necessary for dietary protein restriction to extend lifespan and improve metabolic health in aged, male mice.

Cristal M. Hill
Diana C. Albarado
Christopher D. Morrison
ResearchOpen Access07 Apr 2022
Nature Communications

Volume: 13, P: 1-14
Third word development: Intensifying tropical agriculture: the Indonesian experience

Gordon R. Conway
David S. McCauley
News & Views24 Mar 1983
Nature

Volume: 302, P: 288-289
Anomalous solubility behaviour of C₆₀

Rodney S. Ruoff
Ripudaman Malhotra
Donald C. Lorents
Research11 Mar 1993
Nature

Volume: 362, P: 140-141
Genetic basis of early onset and progression of type 2 diabetes in South Asians

In a cohort of 50,556 South Asian individuals, partitioned polygenic scores helped identify genetic susceptibility to insulin deficiency and unfavorable fat distribution as key drivers of young-onset T2D diagnosis and faster progression to diabetes-related complications.

Sam Hodgson
Alice Williamson
Sarah Finer
ResearchOpen Access26 Nov 2024
Nature Medicine

Volume: 31, P: 323-331
Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

This study uses gene expression predictors for the dorsolateral prefrontal cortex and other brain regions to perform a transcriptomic imputation analysis of schizophrenia, identifying 413 genic associations across 13 brain regions and 36 significantly enriched pathways.

Laura M. Huckins
Amanda Dobbyn
Eli A. Stahl
Research25 Mar 2019
Nature Genetics

Volume: 51, P: 659-674
PICALM modulates autophagy activity and tau accumulation

The protein PICALM/CALM is implicated in Alzheimer’s disease (AD) pathology, but it is unclear how. In this study, the authors show that CALM regulates clearance of the protein tau, which is also implicated in AD pathology, by facilitating endocytosis-dependent autophagy.

Kevin Moreau
Angeleen Fleming
David C. Rubinsztein
ResearchOpen Access22 Sept 2014
Nature Communications

Volume: 5, P: 1-20
Scoping review of the utilization of wearable devices in pediatric and young adult oncology

Lane Collier
Sarah L. Grimshaw
Rachel Conyers
ResearchOpen Access31 Jul 2025
npj Digital Medicine

Volume: 8, P: 1-9

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