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A brain-specific angiogenic mechanism enabled by tip cell specialization

A molecular mechanism for brain-specific angiogenesis operates under the control of Wnt7a/b ligands.

Giel Schevenels
Pauline Cabochette
Benoit Vanhollebeke
ResearchOpen Access03 Apr 2024
Nature

Volume: 628, P: 863-871
Impact of pulmonary African trypanosomes on the immunology and function of the lung

A number of human African trypanosomiasis, or sleeping sickness, patients suffer from respiratory symptoms commonly attributed to cardiac insufficiency. Here, the authors characterise the role of pulmonary Trypanosoma brucei in respiratory infection.

Dorien Mabille
Laura Dirkx
Guy Caljon
ResearchOpen Access18 Nov 2022
Nature Communications

Volume: 13, P: 1-18
Q586B2 is a crucial virulence factor during the early stages of Trypanosoma brucei infection that is conserved amongst trypanosomatids

Sleeping sickness caused by African trypanosome parasites induces a chronic, and potentially lethal, infection in humans. Here, the authors uncover a conserved protein, Q586B2, playing an important regulatory role in Trypanosomatid infection establishment.

Benoit Stijlemans
Patrick De Baetselier
Carl De Trez
ResearchOpen Access27 Feb 2024
Nature Communications

Volume: 15, P: 1-18
Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis

In mouse and human squamous cell carcinoma, loss of function of FAT1 promotes tumour initiation, malignant progression and metastasis through the activation of a hybrid epithelial-to-mesenchymal transition phenotype.

Ievgenia Pastushenko
Federico Mauri
Cédric Blanpain
Research16 Dec 2020
Nature

Volume: 589, P: 448-455
Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1

The human serum protein apolipoprotein L1 (APOL1) is taken up by trypanosomes where it triggers cell death, forming pores in endolysosomal membranes. Vanwalleghem et al.show that APOL1 triggers both lysosomal and mitochondrial membrane permeabilization, and that the latter is responsible for trypanolysis.

Gilles Vanwalleghem
Frédéric Fontaine
Etienne Pays
ResearchOpen Access26 Aug 2015
Nature Communications

Volume: 6, P: 1-10
The molecular arms race between African trypanosomes and humans

Humans can resist infection by African trypanosomes, owing to the trypanolytic activity of apolipoprotein L1 (APOL1), which is associated with two serum complexes, trypanosome lytic factor 1 (TLF1) and TFL2.Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense evade this defence mechanism by expressing resistance proteins and in turn, populations in western Africa can restore resistance to T. b. rhodesiense via sequence variation in APOL1. Pays et. al. review this complex relationship and its evolutionary importance.

Etienne Pays
Benoit Vanhollebeke
David Pérez-Morga
Reviews30 Jun 2014
Nature Reviews Microbiology

Volume: 12, P: 575-584
INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse

Stephane Schurmans and colleagues show that mice lacking the enzyme inositol polyphosphate-5-phosphatase E (Inpp5e) develop a multiorgan disorder with defects in primary cilia. They also report a mutation in human INPP5E in a family with MORM syndrome, a condition similar to Bardet-Biedl syndrome.

Monique Jacoby
James J Cox
Stéphane Schurmans
Research09 Aug 2009
Nature Genetics

Volume: 41, P: 1027-1031
Mechanism of Trypanosoma brucei gambiense resistance to human serum

This study shows that Trypanosoma brucei gambiense resists trypanolytic factors (TLFs) in a multifactorial manner, relying on a hydrophobic β-sheet of the TgsGP glycoprotein, which prevents APOL1 toxicity and induces membrane stiffening, as well as a reduction in sensitivity to APOL1 requiring cysteine protease activity and TLF-1 receptor inactivation owing to a single amino acid substitution.

Pierrick Uzureau
Sophie Uzureau
Etienne Pays
Research21 Aug 2013
Nature

Volume: 501, P: 430-434
APOLs with low pH dependence can kill all African trypanosomes

Recombinant proteins based on APOL1 and APOL3 can kill pathogenic Trypanosoma brucei subspecies, including a variant (rPpMUT) that is effective against T.b. gambiense infection in mice, suggesting that it may serve as a therapy against sleeping sickness.

Frédéric Fontaine
Laurence Lecordier
Etienne Pays
Research18 Sept 2017
Nature Microbiology

Volume: 2, P: 1500-1506
New hemisynthetic derivatives of sphaeropsidin phytotoxins triggering severe endoplasmic reticulum swelling in cancer cells

Aude Ingels
Robert Scott
Véronique Mathieu
ResearchOpen Access25 Jun 2024
Scientific Reports

Volume: 14, P: 1-18
The trypanolytic factor of human serum

Trypanosoma brucei rhodesienseis one of the causative agents of sleeping sickness, owing to its ability to resist lysis by human serum. In this Opinion article, the authors contend that a pore-forming apolipoprotein known as APOL1 is the factor that is responsible for the trypanolytic activity of human serum.

Etienne Pays
Benoit Vanhollebeke
David Pérez-Morga
Reviews01 Jun 2006
Nature Reviews Microbiology

Volume: 4, P: 477-486
Long-term T cell fitness and proliferation is driven by AMPK-dependent regulation of reactive oxygen species

Anouk Lepez
Tiphène Pirnay
Fabienne Andris
ResearchOpen Access10 Dec 2020
Scientific Reports

Volume: 10, P: 1-14
Activation of the endoplasmic reticulum stress sensor IRE1α by the vaccine adjuvant AS03 contributes to its immunostimulatory properties

Charlotte Givord
Iain Welsby
Stanislas Goriely
ResearchOpen Access28 Jun 2018
npj Vaccines

Volume: 3, P: 1-12

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A brain-specific angiogenic mechanism enabled by tip cell specialization

Impact of pulmonary African trypanosomes on the immunology and function of the lung

Q586B2 is a crucial virulence factor during the early stages of Trypanosoma brucei infection that is conserved amongst trypanosomatids

Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis

Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1

The molecular arms race between African trypanosomes and humans

INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse

Mechanism of Trypanosoma brucei gambiense resistance to human serum

APOLs with low pH dependence can kill all African trypanosomes

New hemisynthetic derivatives of sphaeropsidin phytotoxins triggering severe endoplasmic reticulum swelling in cancer cells

The trypanolytic factor of human serum

Long-term T cell fitness and proliferation is driven by AMPK-dependent regulation of reactive oxygen species

Activation of the endoplasmic reticulum stress sensor IRE1α by the vaccine adjuvant AS03 contributes to its immunostimulatory properties

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