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Showing 1–4 of 4 results

Advanced filters: Author: David Przelicki Clear advanced filters

Childhood cerebellar tumours mirror conserved fetal transcriptional programs

Sequencing data from the developing cerebellum are compared with bulk sequencing data from paediatric tumours, providing insights into their potential origins and suggesting that many cerebellar tumours have their origins early in utero.

Maria C. Vladoiu
Ibrahim El-Hamamy
Michael D. Taylor
Research01 May 2019
Nature

Volume: 572, P: 67-73
Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma

Highly recurrent hotspot r.3A>G mutations are identified in U1 splicesomal small nuclear RNAs in about 50% of Sonic hedgehog medulloblastomas, which result in disrupted RNA splicing and the activation of oncogenes.

Hiromichi Suzuki
Sachin A. Kumar
Michael D. Taylor
Research09 Oct 2019
Nature

Volume: 574, P: 707-711
Author Correction: Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma

Laura K. Donovan
Alberto Delaidelli
Michael D. Taylor
Amendments and Corrections27 May 2021
Nature Medicine

Volume: 27, P: 1117-1120
Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma

Intraventricularly delivered monovalent and trivalent CAR T cells exhibit greater therapeutic efficacy as compared with intravenously delivered CAR T cells in medulloblastoma xenograft mouse models and show potency in ependymoma xenograft mouse models.

Laura K. Donovan
Alberto Delaidelli
Michael D. Taylor
Research27 Apr 2020
Nature Medicine

Volume: 26, P: 720-731