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Earth System Models are widely used for projecting future streamflow. The authors show that the models underestimate declines in global streamflow with climate change, indicating that a future water crisis could be more severe than previously estimated.

Sandeford challenges the standard model of intensification using an ethnographic dataset that describes food production in 40 human societies ranging in complexity from small-scale foraging bands to large-scale agricultural states.

A nested orbit-to-ground approach for microbial landscape patterns at different scales, tested in the high Andes, provides a machine learning-based search tool for detecting biosignatures on terrestrial planets.

Efficient statistical emulation of melting land ice under various climate scenarios to 2100 indicates a contribution from melting land ice to sea level increase of at least 13 centimetres sea level equivalent.

A global multi-taxon extinction risk assessment of freshwater fauna for The IUCN Red List of Threatened Species finds one-quarter of species to be at high risk of extinction.

Failing to keep the increase of global mean temperature below 1.5 °C will have multiple negative implications. A study maps the annual changes in cooling demand, showing the most affected countries by warming, if the global mean temperature rises from 1.5 °C to 2.0 °C

Analysis of HbA1c and FPG levels across 117 population-based studies demonstrates regional variation in prevalence of previously undiagnosed screen-detected diabetes using one or both measures and suggests that use of elevated FPG alone could underestimate diabetes prevalence in low- and middle-income countries.

City-level analysis of data from the SALURBAL project shows vast heterogeneity in life expectancy across cities within the same country, in addition to substantive differences in causes of death among nine Latin American countries, revealing modifiable factors that could be leveraged by municipal-level policies aimed toward improving health in urban environments.

Analyses of neuroimaging datasets from 5,306 participants across 15 countries found generally larger brain-age gaps in Latin American compared with non-Latin American populations, which were influenced by disparities in socioeconomic and health-related factors.

Using 13 functional traits we characterize the Amazonian trees and the communities they form. Amazonian tree communities are distributed along a fast-slow-spectrum. This results in clear differences in traits among these forests, as well as their biomass and biomass productivity.

Major sediment-hosted base metal deposits are located within 200 km of the border between thick and thin lithosphere, according to statistical comparisons between global lithospheric thickness and known deposit locations.

The Seshat database has made it possible to reveal large-scale patterns in human cultural evolution. Here, Shin et al. investigate transitions in social complexity and find alternating thresholds of polity size and information processing required for further sociopolitical development.

It is thought that the Earth's atmospheric carbon dioxide concentrations did not fall below about 200–250 parts per million during the past 24 million years despite the drawdown of atmospheric carbon dioxide by high rates of global silicate rock weathering. Simulations of terrestrial and geochemical carbon cycles now suggest that limited vegetation activity in regions of active mountain ranges effectively diminished biotic-driven silicate rock weathering and thereby provided a negative feedback mechanism to stabilize carbon dioxide concentrations.

This study uses transfer learning to identify seismic eruption precursors shared among volcanoes, enabling accurate forecasting even at data-scarce sites. Results show that seismic patterns exhibit ergodicity, supporting scalable models to improve volcanic monitoring and risk mitigation.

The CMS Collaboration reports the study of three simultaneous hard interactions between quarks and gluons in proton–proton collisions. This manifests through the concurrent production of three J/ψ mesons, which consist of a charm-quark–antiquark pair.

An analysis of regional variations in global inland water surface area, dissolved CO₂ and gas transfer velocity yields a global CO₂ evasion rate of 2.1 × 10¹⁵ grams of carbon per year, which is higher than previous estimates owing to a larger contribution from streams and rivers.

A global zoning scheme is proposed to limit the environmental costs of road building while maximizing its benefits for human development, by discriminating among areas where road building would have high environmental costs but relatively low agricultural advantage, areas where strategic road improvements could promote agricultural production with relatively modest environmental costs, and ‘conflict areas’ where road building may have large agricultural benefits but also high environmental costs.

The Vertebrate Genome Project has used an optimized pipeline to generate high-quality genome assemblies for sixteen species (representing all major vertebrate classes), which have led to new biological insights.

The CMS Collaboration reports evidence for off-shell Higgs boson contributions in the production of Z boson pairs, and measures the width of the Higgs boson, which is inversely related to its lifetime.

The Candida albicans toxin, candidalysin, is embedded in an unusual conserved precursor peptide sequence (Ece1). The precursor is not required to block premature pore-forming toxicity, but rather to prevent candidalysin auto-aggregation.

The most up-to-date combination of results on the properties of the Higgs boson is reported, which indicate that its properties are consistent with the standard model predictions, within the precision achieved to date.

A survey of genetic variation in Native American and Siberian populations reveals that Native Americans are descended from at least three streams of gene flow from Asia: after the initial peopling of the continent there was a southward expansion facilitated by the coast, with sequential population splits and little gene flow after divergence, especially in South America.

The authors analyse tree responses to an extreme heat and drought event across South America to understand long-term climate resistance. While no more sensitive to this than previous lesser events, forests in drier climates showed the greatest impacts and thus vulnerability to climate extremes.

Glacier snowlines in both the European Alps and the Southern Alps of New Zealand have retreated over the past century. An analysis of glacier fluctuations in New Zealand over the past 11,000 years suggests that this synchronous behaviour is unique to the past few hundred years.

Integrating inventory data with machine learning models reveals the global composition of tree types—needle-leaved evergreen individuals dominate, followed by broadleaved evergreen and deciduous trees—and climate change risks.

This Registered Report presents evidence from 87 countries and regions showing that brief emotion-regulation interventions consistently reduced negative emotions and increased positive emotions during the COVID-19 pandemic.

Enterococcus faecalis has been reported to inhibit Candida albicans virulence via secretion of the bacteriocin EntV. Here, the authors present the crystal structure and characterise the antifungal properties of this peptide in numerous in vitro and in vivo assays.

Biomineral armour is known in a number of diverse creatures but has not previously been observed in insects. Here, the authors report on the discovery and characterization of high-magnesium calcite armour which overlays the exoskeletons of leaf-cutter ants.

Acclimation of tree photosynthesis to warming may be affected by elevated CO₂. Here, the authors show that mature boreal conifers may be able to maintain leaf-level C uptake under warming and elevated CO₂ even if optimum temperature of photosynthesis does not track increased temperature.

Host microbiomes are feasible sources for drug discovery. Here, using large-scale isolations, bioactivity assays and omics, the authors uncover the antimicrobial potential of insect-associated Streptomyces and identify a compound, cyphomycin, active against multidrug-resistant fungal pathogens.

The fungal pathogen Candida auris is resistant to multiple drugs including the common antifungal fluconazole. Here, Iyer et al. identify a compound that potentiates fluconazole activity against C. auris in vitro and in vivo by inhibiting a major efflux pump and thus increasing intracellular fluconazole accumulation.

Making sure the night sky stays dark near astronomical observatories makes good sense. For radioastronomers the problem is more difficult, but the solution is the same.

Previous genetic studies have suggested that the Americas were peopled by a single founding population of Eurasian origin, but a genome-wide study of 30 Native American groups shows that Amazonian Native Americans also have a second source of ancestry that is deeply related to indigenous Australians, New Guineans and Andaman Islanders.

There is an urgent need for novel strategies to combat life-threatening fungal infections. Here, Revie et al. identify a compound that induces alterations in fungal membranes, synergizes with azole antifungals against the pathogen Candida albicans, and inhibits virulence traits and biofilm formation in animal models of infection.

Analyses of drivers of water stress are used to predict likely trajectories of the Amazon forest system and suggests potential actions that could prevent system collapse.

This work reveals a mechanism of cGAS- and STING-dependent type I IFN induction in response to biofilm-associated Candida albicans DNA packaged in extracellular vesicles.