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Showing 1–10 of 10 results
Advanced filters: Author: David Rhyner Clear advanced filters

  • An inflammatory process may increase the risk of arrhythmias after transcatheter aortic valve replacement. Here, the authors show that periprocedural treatment with colchicine may reduce the incidence of new-onset arrhythmias and subclinical leaflet thrombosis after transcatheter aortic valve replacement.

    • Christoph Ryffel
    • Jonas Lanz
    • Thomas Pilgrim
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11

  • A clinical decision support system for diagnosis of myocardial infarction, based on machine learning models that use a single measurement of high-sensitivity troponin, outperforms clinical guidelines that use fixed cardiac troponin thresholds for diagnosis.

    • Dimitrios Doudesis
    • Kuan Ken Lee
    • Stephen W. Smith
    ResearchOpen Access
    Nature Medicine
    Volume: 29, P: 1201-1210

  • Here, the authors show that physiological alpha-synuclein supports mitochondrial ATP homeostasis via interactions with ATP synthase and AK2, whereas its disease-linked mutants, truncated forms, and aggregates lose these interactions.

    • Tetiana Serdiuk
    • Yanick Fleischmann
    • Roland Riek
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • In hepatocellular carcinoma driven by non-alcoholic steatohepatitis, aberrant T cell activation and impaired immune surveillance seem to make hepatocellular carcinoma less responsive to anti-PD1 or anti-PDL1 immunotherapy.

    • Dominik Pfister
    • Nicolás Gonzalo Núñez
    • Mathias Heikenwalder
    ResearchOpen Access
    Nature
    Volume: 592, P: 450-456

  • Recent data from early clinical trials in melanoma patients carrying mutations in the B-RAF gene have shown promising results with the B-RAF kinase inhibitor PLX4032; however, many patients eventually develop resistance to this treatment. Two papers now uncover possible mechanisms of resistance to PLX4032. One paper shows that upregulation of MAP3K8 (which encodes COT) can confer resistance of melanoma cells to B-RAF inhibitors, whereas another paper found that melanomas can acquire resistance due to mutations of N-RAS or increased expression of PDGFRβ. Each of these resistance mechanisms seems to apply to at least some patients on recent PLX4032 trial, whereas, surprisingly, so far no secondary B-RAF mutations have been observed.

    • Cory M. Johannessen
    • Jesse S. Boehm
    • Levi A. Garraway
    Research
    Nature
    Volume: 468, P: 968-972

  • Determination of prognosis in patients with status epilepticus (SE)—a life-threatening state of ongoing or repetitive seizures—is difficult, and current outcome prediction scales do not take into account novel outcome markers, such as EEG and imaging findings. Here, Sutter et al. review the available data on major prognostic determinants of outcome in SE, and propose a novel paradigm for assessment of these predictive factors over the course of the seizure.

    • Raoul Sutter
    • Peter W. Kaplan
    • Stephan Rüegg
    Reviews
    Nature Reviews Neurology
    Volume: 9, P: 525-534