SUMOylation is a post-translational protein modification that affects many eukaryotic cellular processes. It is shown here that cellular infection with Listeria monocytogenes induces degradation of one of the essential SUMOylation enzymes, Ubc9, through a mechanism that involves a bacterial toxin, listeriolysin O. This effect on SUMOylation may support efficient infection by Listeria.
- David Ribet
- Mélanie Hamon
- Pascale Cossart
