Nature Search

Comprehensive molecular characterization of mitochondrial genomes in human cancers

Analysis of mitochondrial genomes (mtDNA) by using whole-genome sequencing data from 2,658 cancer samples across 38 cancer types identifies hypermutated mtDNA cases, frequent somatic nuclear transfer of mtDNA and high variability of mtDNA copy number in many cancers.

Yuan Yuan
Young Seok Ju
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Genetics

Volume: 52, P: 342-352
Butler enables rapid cloud-based analysis of thousands of human genomes

Efficient, large-scale genomic analysis is facilitated on the cloud by a computational tool with error-diagnosing and self-healing capabilities.

Sergei Yakneen
Sebastian M. Waszak
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Biotechnology

Volume: 38, P: 288-292
The origin of baryons in the Universe

MICHAEL S. TURNER
DAVID N. SCHRAMM
Research24 May 1979
Nature

Volume: 279, P: 303-305
Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission

Post-international travel quarantine has been widely implemented to mitigate SARS-CoV-2 transmission, but the impacts of such policies are unclear. Here, the authors used linked genomic and contact tracing data to assess the impacts of a 14-day quarantine on return to England in summer 2020.

Dinesh Aggarwal
Andrew J. Page
Ewan M. Harrison
ResearchOpen Access23 Feb 2022
Nature Communications

Volume: 13, P: 1-13
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

In this study, Aggarwal and colleagues perform prospective sequencing of SARS-CoV-2 isolates derived from asymptomatic student screening and symptomatic testing of students and staff at the University of Cambridge. They identify important factors that contributed to within university transmission and onward spread into the wider community.

Dinesh Aggarwal
Ben Warne
Ian G. Goodfellow
ResearchOpen Access08 Feb 2022
Nature Communications

Volume: 13, P: 1-16
Microglia dysfunction, neurovascular inflammation and focal neuropathologies are linked to IL-1- and IL-6-related systemic inflammation in COVID-19

The authors show that brain inflammation in COVID-19 correlates with viral load, systemic inflammation and virus-sensing pattern recognition receptors. Microglial dysfunction occurs at sites of vascular inflammation with myelin injury and synapse loss.

Rebeka Fekete
Alba Simats
Ádám Dénes
ResearchOpen Access06 Mar 2025
Nature Neuroscience

Volume: 28, P: 558-576
China tests giant air cleaner to combat smog

The prototype offers an innovative solution to a major public-health problem.

David Cyranoski
News06 Mar 2018
Nature

Volume: 555, P: 152-153
Allosteric modulation of beta1 integrin function induces lung repair in animal model of emphysema.

Rehab Al-Jamal
Linda Wilson
David J. Harrison
ResearchOpen Access13 Jul 2007
Nature Precedings

P: 1
A new method for monitoring temporal trends in the acidity of fresh waters

Andrew L. Herczeg
Wallace S. Broecker
David W. Schindler
Research09 May 1985
Nature

Volume: 315, P: 133-135
Is the end of particle proliferation at hand?

Roland Pease
David Lindley
News19 Oct 1989
Nature

Volume: 341, P: 555
Indian earthquake

David Lindley
News01 Aug 1988
Nature

Volume: 334, P: 640
Kobe earthquake shatters faith in engineers

David Swinbanks
News26 Jan 1995
Nature

Volume: 373, P: 273
Striking similarities with US quake

DAVID SWINBANKS
News26 Jan 1995
Nature

Volume: 373, P: 273
Tokyo quake

David Swinbanks
News06 Feb 1992
Nature

Volume: 355, P: 489
Bone marrow adipocytes fuel emergency hematopoiesis after myocardial infarction

Zhang et al. show that bone marrow fatty acid metabolism fuels expanded leukocyte production after myocardial infarction and, based on mouse, pig and human data, suggest that lipolysis in marrow adipocytes provides fatty acids to hematopoietic stem cells.

Shuang Zhang
Alexandre Paccalet
Matthias Nahrendorf
Research05 Dec 2023
Nature Cardiovascular Research

Volume: 2, P: 1277-1290
Whole-genome sequencing of patients with rare diseases in a national health system

Whole-genome sequencing and phenotype data sharing are introduced in a national health system to streamline diagnosis and to discover coding and non-coding variants that cause rare diseases.

Ernest Turro
William J. Astle
Willem H. Ouwehand
Research24 Jun 2020
Nature

Volume: 583, P: 96-102
Genomic reconstruction of the SARS-CoV-2 epidemic in England

A study of the evolution of the SARS-CoV-2 virus in England between September 2020 and June 2021 finds that interventions capable of containing previous variants were insufficient to stop the more transmissible Alpha and Delta variants.

Harald S. Vöhringer
Theo Sanderson
Moritz Gerstung
ResearchOpen Access14 Oct 2021
Nature

Volume: 600, P: 506-511
Dislocation avalanches are like earthquakes on the micron scale

Metallic microsamples deform in a sequence of abrupt strain bursts. Here, the authors demonstrate by analysing the elastic waves emitted by these bursts that this intermittent process resembles earthquakes in several aspects, although on completely different spatial and temporal scales.

Péter Dusán Ispánovity
Dávid Ugi
István Groma
ResearchOpen Access13 Apr 2022
Nature Communications

Volume: 13, P: 1-10
Dependence of galaxy properties on viewing angle

David Burstein
Martha P. Haynes
S. M. Faber
Reviews10 Oct 1991
Nature

Volume: 353, P: 515-521
Chronic lymphocytic leukemia (CLL) with Reed–Sternberg-like cells vs Classic Hodgkin lymphoma transformation of CLL: does this distinction matter?

Rebecca L. King
Alia Gupta
Sameer A. Parikh
ResearchOpen Access28 Jan 2022
Blood Cancer Journal

Volume: 12, P: 1-7
Burdens of type 2 diabetes and cardiovascular disease attributable to sugar-sweetened beverages in 184 countries

Estimates from the Global Dietary Database indicated that 2.2 million new type 2 diabetes and 1.2 million new cardiovascular disease cases were attributable to sugar-sweetened beverages worldwide in 2020, with the highest burdens in sub-Saharan Africa, Latin America and the Caribbean.

Laura Lara-Castor
Meghan O’Hearn
Rubina Hakeem
ResearchOpen Access06 Jan 2025
Nature Medicine

Volume: 31, P: 552-564
Budget protection for research

David Dickson
News11 Feb 1982
Nature

Volume: 295, P: 447-448
Earthquake forecasting from paleoseismic records

There is no universal model for large earthquake recurrence, and an ensemble forecasting approach is desirable when dealing with paleoseismic records with few data points and large measurement errors.

Ting Wang
Jonathan D. Griffin
Jie Kang
ResearchOpen Access02 Mar 2024
Nature Communications

Volume: 15, P: 1-12
The unpredictable Earth

David Bercovici
Comments & Opinion21 Sept 1995
Nature

Volume: 377, P: 272
Never spare the rod

David W. Kingsbury
Books & Arts23 Dec 1987
Nature

Volume: 330, P: 620
Synchrotron bids seek ways to raise money

Declan Butler
David Dickson
News09 May 1996
Nature

Volume: 381, P: 100
A sub-millimetre aperture synthesis array for nonsolar planet detection

Dayton L. Jones
David J. Diner
Research05 Jan 1989
Nature

Volume: 337, P: 51-53
Immune responses against SARS-CoV-2 variants after two and three doses of vaccine in B-cell malignancies: UK PROSECO study

Lim and colleagues present the UK PROSECO study where they assess humoral and cellular immune responses to one, two and three doses of vaccination against SARS-CoV-2 in patients with B-cell malignancies in a prospective observational study.

Sean H. Lim
Beth Stuart
David Goldblatt
ResearchOpen Access24 Mar 2022
Nature Cancer

Volume: 3, P: 552-564
Author Correction: Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

Esther Rheinbay
Morten Muhlig Nielsen
Christian von Mering
Amendments and CorrectionsOpen Access25 Jan 2023
Nature

Volume: 614, P: E40
Ofatumumab maintenance prolongs progression-free survival in relapsed chronic lymphocytic leukemia: final analysis of the PROLONG study

Marinus van Oers
Lukas Smolej
Christian Geisler
ResearchOpen Access04 Dec 2019
Blood Cancer Journal

Volume: 9, P: 1-9
The oldest cosmic light

The cosmic microwave background is a faint glow of light left over from the Big Bang. It fills the entire sky and records the Universe's early history. Two independent experts outline what we know about this ancient light, both theoretically and observationally.

David Spergel
Brian Keating
News & Views11 Feb 2015
Nature

Volume: 518, P: 170-171
A second generation human haplotype map of over 3.1 million SNPs

A consortium reports the tripling of the number of genetic markers in Phase II of the International HapMap Project. This map of human genetic variation will continue to revolutionize discovery of susceptibility loci in common genetic diseases, and study of genes under selection in humans.

Kelly A. Frazer (Principal Investigator)
Dennis G. Ballinger
John Stewart
Research18 Oct 2007
Nature

Volume: 449, P: 851-861
Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain

Nay Wei Soong
David R. Hinton
Norman Arnheim
Research01 Dec 1992
Nature Genetics

Volume: 2, P: 318-323
Monitoring Underground Explosions

DAVID DAVIES
Research05 Jan 1973
Nature

Volume: 241, P: 19-24
Correction: Corrigendum: Signatures of mutational processes in human cancer

Ludmil B. Alexandrov
Serena Nik-Zainal
Michael R. Stratton
Amendments and Corrections09 Oct 2013
Nature

Volume: 502, P: 258
Heterogeneity-driven phenotypic plasticity and treatment response in branched-organoid models of pancreatic ductal adenocarcinoma

Branched organoids embedded in collagen gels can recapitulate the phenotypic landscape and pronounced molecular and morphological heterogeneity of pancreatic ductal adenocarcinoma.

Aristeidis Papargyriou
Mulham Najajreh
Maximilian Reichert
ResearchOpen Access10 Dec 2024
Nature Biomedical Engineering

Volume: 9, P: 836-864
Immunoglobulin genes: Inversion for gene construction

David Baltimore
News & Views02 Jan 1986
Nature

Volume: 319, P: 12-13
Observation of quantum entanglement with top quarks at the ATLAS detector

Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s = 13 TeV and an integrated luminosity of 140 fb⁻¹.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access18 Sept 2024
Nature

Volume: 633, P: 542-547
GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements

Investigation of variation in three cohorts has identified multiple genetic signals associated with the pregnancy-specific liver disorder, intrahepatic cholestasis of pregnancy, giving insight into the disease which can cause preterm birth and stillbirth.

Peter H. Dixon
Adam P. Levine
Catherine Williamson
ResearchOpen Access17 Aug 2022
Nature Communications

Volume: 13, P: 1-18
Repositioning of the global epicentre of non-optimal cholesterol

From 1980 to 2018, the levels of total and non-high-density lipoprotein cholesterol increased in low- and middle-income countries, especially in east and southeast Asia, and decreased in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe.

Cristina Taddei
Bin Zhou
Majid Ezzati
ResearchOpen Access03 Jun 2020
Nature

Volume: 582, P: 73-77
US budget described in outline

David Dickson
News11 Feb 1982
Nature

Volume: 295, P: 448-449
Stress-driven recurrence and precursory moment-rate surge in caldera collapse earthquakes

The initiation and rupture extent of earthquakes are controlled by stress heterogeneity, according to analysis of seismicity and deformation during caldera collapse of Kilauea Volcano.

Paul Segall
Mark V. Matthews
Kyle R. Anderson
Research05 Feb 2024
Nature Geoscience

Volume: 17, P: 264-269
SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease

Serological analysis and infection outcomes of participants in the multi-center, prospectively enrolled OCTAVE cohort, comprising 2,686 participants with immune-suppressive diseases who recieved two COVID-19 vaccines, reveals specific clinical phenotypes that might benefit from specific COVID-19 therapeutic strategies.

Eleanor Barnes
Carl S. Goodyear
Deborah Richardson
ResearchOpen Access06 Jul 2023
Nature Medicine

Volume: 29, P: 1760-1774
Author Correction: Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig

Yulia Rubanova
Ruian Shi
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

Kadir C. Akdemir
Victoria T. Le
Christian von Mering
Amendments and CorrectionsOpen Access21 Mar 2023
Nature Genetics

Volume: 55, P: 1079
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

Genome-wide association analyses of 41,917 bipolar disorder cases and 371,549 controls of European ancestry provide new insights into the etiology of this disorder and identify novel therapeutic leads and potential opportunities for drug repurposing.

Niamh Mullins
Andreas J. Forstner
Ole A. Andreassen
Research17 May 2021
Nature Genetics

Volume: 53, P: 817-829
Author Correction: Pathway and network analysis of more than 2500 whole cancer genomes

Matthew A. Reyna
David Haan
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: Genomic footprints of activated telomere maintenance mechanisms in cancer

Lina Sieverling
Chen Hong
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

Bernardo Rodriguez-Martin
Eva G. Alvarez
Christian von Mering
Amendments and CorrectionsOpen Access21 Mar 2023
Nature Genetics

Volume: 55, P: 1080
Squidpy: a scalable framework for spatial omics analysis

Squidpy enables comprehensive analysis and visualization of spatial omics data and image with high efficiency.

Giovanni Palla
Hannah Spitzer
Fabian J. Theis
ResearchOpen Access31 Jan 2022
Nature Methods

Volume: 19, P: 171-178

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