It is detailed that adult mouse neural stem cells (NSCs) express higher endogenous levels of Sox2 and c-Myc than embryonic stem cells, and that exogenous Oct4 together with either Klf4or c-Myc are sufficient to generate iPS cells from NSCs. The number of reprogramming factors can be reduced when using somatic cells that endogenously express appropriate levels of complementing factors.
- Jeong Beom Kim
- Holm Zaehres
- Hans R. Schöler
