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Showing 1–3 of 3 results
Advanced filters: Author: David Speedman Clear advanced filters

  • ELOVLs are membrane-embedded enzymes that elongate very long chain fatty acids, precursors of sphingolipids and ceramides. The first crystal structure of a human ELOVL reveals an unexpected reaction mechanism, suggesting potential approaches for inhibition in disease.

    • Laiyin Nie
    • Tomas C. Pascoa
    • Elisabeth P. Carpenter
    Research
    Nature Structural & Molecular Biology
    Volume: 28, P: 512-520

  • The X-ray crystal structure of the potassium channel TASK-1 reveals the presence of an X-gate, which traps small-molecule inhibitors in the intramembrane vestibule and explains their low washout rates from the channel.

    • Karin E. J. Rödström
    • Aytuğ K. Kiper
    • Elisabeth P. Carpenter
    Research
    Nature
    Volume: 582, P: 443-447