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Showing 1–5 of 5 results
Advanced filters: Author: David Sprinzak Clear advanced filters

  • Fat and Dachsous are large cadherins that regulate planar polarity as a receptor:ligand pair. Here, authors determine the structure of the Fat:Dachsous complex to uncover the molecular determinants of binding and posttranslational modification.

    • Elliot Medina
    • Yathreb Easa
    • Vincent C. Luca
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11

  • Taylor et al. show that tumor cells promote white adipose tissue (WAT) wasting and cachexia by overactivation of Notch1 signaling and retinoic acid production in distant WAT endothelium, which can be therapeutically targeted to inhibit wasting.

    • Jacqueline Taylor
    • Leonie Uhl
    • Andreas Fischer
    ResearchOpen Access
    Nature Cancer
    Volume: 4, P: 1544-1560

  • Notch and Delta are transmembrane proteins that allow neighbouring cells to communicate during development. Here, quantitative time-lapse microscopy has been used to show that the response of Notch to Delta on a neighbouring cell is graded, whereas its response to Delta on the same cell is sharp and occurs at a fixed threshold. A mathematical model explores how this new design principle enhances the sharpness of developmental boundaries set by classical lateral inhibition.

    • David Sprinzak
    • Amit Lakhanpal
    • Michael B. Elowitz
    Research
    Nature
    Volume: 465, P: 86-90

  • The periodic organization of cells is typically associated with mechanisms based on intercellular signaling such as lateral inhibition and Turing patterning. Here the authors show that hair cells in the inner ear rearrange gradually into a checkerboard-like pattern through a tissue-wide shear motion that coordinates intercalation and delamination events.

    • Roie Cohen
    • Liat Amir-Zilberstein
    • David Sprinzak
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12