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Showing 51–79 of 79 results

Advanced filters: Author: David W. Goodrich Clear advanced filters

Author Correction: Large loss of CO₂ in winter observed across the northern permafrost region

Susan M. Natali
Jennifer D. Watts
Donatella Zona
Amendments and Corrections08 Nov 2019
Nature Climate Change

Volume: 9, P: 1005
Rare variant analyses in 51,256 type 2 diabetes cases and 370,487 controls reveal the pathogenicity spectrum of monogenic diabetes genes

Rare variant analyses identify a new type 2 diabetes risk allele near the LEP gene, which encodes leptin, and other risk alleles of intermediate penetrance in genes previously implicated in monogenic forms of diabetes.

Alicia Huerta-Chagoya
Philip Schroeder
Josep M. Mercader
ResearchOpen Access08 Oct 2024
Nature Genetics

Volume: 56, P: 2370-2379
Environment dominates over host genetics in shaping human gut microbiota

Statistical analyses of a metagenomics-sequenced human cohort identify a relatively minor role for genetics in determining microbiome composition and show that several human phenotypes are as strongly associated with the gut microbiome as with host genetics.

Daphna Rothschild
Omer Weissbrod
Eran Segal
Research28 Feb 2018
Nature

Volume: 555, P: 210-215
The effect of LRRK2 loss-of-function variants in humans

Analysis of large genomic datasets, including gnomAD, reveals that partial LRRK2 loss of function is not strongly associated with diseases, serving as an example of how human genetics can be leveraged for target validation in drug discovery.

Nicola Whiffin
Irina M. Armean
Daniel G. MacArthur
ResearchOpen Access27 May 2020
Nature Medicine

Volume: 26, P: 869-877
Genomic autopsy to identify underlying causes of pregnancy loss and perinatal death

In a new study including 200 families who experienced perinatal death, adding genomic analyses to standard autopsies improved the identification of underlying pathogenic causes and informed genetic counseling.

Alicia B. Byrne
Peer Arts
Hamish S. Scott
ResearchOpen Access19 Jan 2023
Nature Medicine

Volume: 29, P: 180-189
The emergence of transcriptional identity in somatosensory neurons

Neuronal targets mediate the emergence of somatosensory neuron subtypes by altering the expression of neuronal transcription factors.

Nikhil Sharma
Kali Flaherty
David D. Ginty
Research08 Jan 2020
Nature

Volume: 577, P: 392-398
Author Correction: A genomic mutational constraint map using variation in 76,156 human genomes

Siwei Chen
Laurent C. Francioli
Konrad J. Karczewski
Amendments and Corrections15 Jan 2024
Nature

Volume: 626, P: E1
Phenome-based approach identifies RIC1-linked Mendelian syndrome through zebrafish models, biobank associations and clinical studies

Integrated use of an animal model, a biobank for common diseases and a rare Mendelian disease leads to the discovery of a new syndrome and its pathological mechanism.

Gokhan Unlu
Xinzi Qi
Ela W. Knapik
Research13 Jan 2020
Nature Medicine

Volume: 26, P: 98-109
The retinoblastoma tumor suppressor protein is required for efficient processing and repair of trapped topoisomerase II-DNA-cleavable complexes

Hai Xiao
David W Goodrich
Research01 Aug 2005
Oncogene

Volume: 24, P: 8105-8113
Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity

Juan E Moyron-Quiroz
Javier Rangel-Moreno
Troy D Randall
Research15 Aug 2004
Nature Medicine

Volume: 10, P: 927-934
Author Correction: The effect of LRRK2 loss-of-function variants in humans

Nicola Whiffin
Irina M. Armean
Daniel G. MacArthur
Amendments and Corrections22 Jan 2021
Nature Medicine

Volume: 27, P: 355
The effects of fish meal substitution by clam meal on the growth and health of Florida pompano (Trachinotus carolinus)

H.-Michael Habte-Tsion
Marty Riche
Carlie S. Perricone
ResearchOpen Access11 May 2022
Scientific Reports

Volume: 12, P: 1-16
The retinoblastoma tumor-suppressor gene, the exception that proves the rule

D W Goodrich
Reviews28 Aug 2006
Oncogene

Volume: 25, P: 5233-5243
Expression of p16 induces transcriptional downregulation of the RB gene

Xianjun Fang
Xiaomei Jin
Gordon B Mills
Research21 Jan 1998
Oncogene

Volume: 16, P: 1-8
Adenovirus-mediated N5 gene transfer inhibits tumor growth and metastasis of human carcinoma in nude mice

Shenmin Yin
Wang Bailiang
David W Goodrich
Research24 Jul 2002
Cancer Gene Therapy

Volume: 9, P: 665-672
Total daily energy expenditure has declined over the past three decades due to declining basal expenditure, not reduced activity expenditure

Using a database of doubly labelled water energy expenditure measurements spanning more than 30 years, Speakman and colleagues show that total energy expenditure in humans has declined over time, while adjusted physical activity energy expenditure has increased over time.

John R. Speakman
Jasper M. A. de Jong
William W. Wong
Research26 Apr 2023
Nature Metabolism

Volume: 5, P: 579-588
Increased Basal REM Sleep But No Difference in Dark Induction or Light Suppression of REM Sleep in Flinders Rats with Cholinergic Supersensitivity

Ruth M Benca
David E Overstreet
William H Obermeyer
Research01 Jul 1996
Neuropsychopharmacology

Volume: 15, P: 45-51
Nuclear localization is required for induction of apoptotic cell death by the Rb-associated p84N5 death domain protein

Randall L Evans
Bryan S Poe
David W Goodrich
Research05 Jul 2002
Oncogene

Volume: 21, P: 4691-4695
Functional imagery training versus motivational interviewing for weight loss: a randomised controlled trial of brief individual interventions for overweight and obesity

Linda Solbrig
Ben Whalley
Jackie Andrade
Research05 Sept 2018
International Journal of Obesity

Volume: 43, P: 883-894
Author Correction: Genomic autopsy to identify underlying causes of pregnancy loss and perinatal death

Alicia B. Byrne
Peer Arts
Hamish S. Scott
Amendments and Corrections10 Jul 2023
Nature Medicine

Volume: 30, P: 302
Characterization of a new intrabody directed against the N-terminal region of human p53

Pascale A Cohen
Jean-Claude Mani
David P Lane
Research12 Oct 1998
Oncogene

Volume: 17, P: 2445-2456
Non-canonical functions of the RB protein in cancer

This Opinion discusses studies indicating a direct role of RB in chromatin regulation and DNA repair. The authors propose that a non-canonical RB pathway exists, which is independent of the function of RB in cell cycle regulation and which contributes to cancer progression.

Frederick A. Dick
David W. Goodrich
Nicholas J. Dyson
Reviews24 Apr 2018
Nature Reviews Cancer

Volume: 18, P: 442-451
Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect

Almost 200 million people worldwide are chronically infected with hepatitis C virus. Current treatments are poorly tolerated and not wholly effective, so new drugs are needed. Here, a potent new inhibitor of hepatitis C virus is described. This inhibitor targets the viral protein NS5A, and shows potential as part of a therapeutic regimen based on a combination of viral inhibitors.

Min Gao
Richard E. Nettles
Lawrence G. Hamann
Research21 Apr 2010
Nature

Volume: 465, P: 96-100
Earlier snowmelt may lead to late season declines in plant productivity and carbon sequestration in Arctic tundra ecosystems

Donatella Zona
Peter M. Lafleur
Walter C. Oechel
ResearchOpen Access21 Mar 2022
Scientific Reports

Volume: 12, P: 1-10
The NOGO receptor NgR2, a novel αVβ3 integrin effector, induces neuroendocrine differentiation in prostate cancer

Fabio Quaglia
Shiv Ram Krishn
Lucia R. Languino
ResearchOpen Access07 Nov 2022
Scientific Reports

Volume: 12, P: 1-14
Pan-cancer molecular analysis of the RB tumor suppressor pathway

Erik Knudsen et al. present a pan-cancer analysis of the RB tumor suppressor protein pathway in 31 tumor types. They find that pathway deregulation is multi-faceted with context dependent association with survival. However, gene expression features are surprisingly invariant and support new therapeutic targets.

Erik S. Knudsen
Ram Nambiar
Agnieszka K. Witkiewicz
ResearchOpen Access02 Apr 2020
Communications Biology

Volume: 3, P: 1-12
Large-scale mapping of cortical alterations in 22q11.2 deletion syndrome: Convergence with idiopathic psychosis and effects of deletion size

Daqiang Sun
Christopher R. K. Ching
Carrie E. Bearden
ResearchOpen Access13 Jun 2018
Molecular Psychiatry

Volume: 25, P: 1822-1834
High flux novel polymeric membrane for renal applications

Christa N. Hestekin
Efecan Pakkaner
Ira Kurtz
ResearchOpen Access20 Jul 2023
Scientific Reports

Volume: 13, P: 1-11
Long-term dataset on aquatic responses to concurrent climate change and recovery from acidification

Taylor H. Leach
Luke A. Winslow
Kevin C. Rose
ResearchOpen Access10 Apr 2018
Scientific Data

Volume: 5, P: 1-12

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