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Showing 1–2 of 2 results
Advanced filters: Author: Davide Moiani Clear advanced filters

  • A discovery pipeline integrating time-resolved HT-SAXS and fragment screening identifies chemical leads targeting exemplary allosteric states of mitochondrial oxidoreductase apoptosis-inducing factor (AIF).

    • Chris A. Brosey
    • Todd M. Link
    • John A. Tainer
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 20, P: 1199-1209

  • PARG catalyzes the removal of poly(ADP-ribose) (PAR) from target proteins and executes critical functions in the DNA damage response. Here the authors provide structural and biological insight with small molecule PARG inhibitors and show that PARG inhibition sensitizes cells to ionizing radiation and kills cancer cells through replication fork defects.

    • Jerry H. Houl
    • Zu Ye
    • John A. Tainer
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15