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Showing 1–7 of 7 results
Advanced filters: Author: Daylon James Clear advanced filters

  • An oral formulation of an antiangiogenic drug may allow long-term anti-cancer therapy.

    • Daylon James
    • Sina Rabbany
    • Shahin Rafii
    News & Views
    Nature Biotechnology
    Volume: 26, P: 769-770

  • This study describes the conversion of human fetal and adult vascular endothelial cells into engraftable haematopoietic progenitors by transduction with some transcription factors and then culture on a vascular niche feeder layer; the haematopoietic progenitors may be useful for the generation of engraftable healthy and long-lasting haematopoietic cells for treatment of inherited and acquired blood disorders.

    • Vladislav M. Sandler
    • Raphael Lis
    • Shahin Rafii
    Research
    Nature
    Volume: 511, P: 312-318

  • Adult stem cells are an ethically attractive alternative to embryonic stem cells for obtaining tissues for therapeutic purposes. However, no standardized methods exist to obtain such cells reliably from adults, and then convert them into different tissues. However, a system has been developed to generate large numbers of stem cells from the adult testicle, based on the presence of a novel marker (GPR125), specifically on the stem cell surface.

    • Marco Seandel
    • Daylon James
    • Shahin Rafii
    Research
    Nature
    Volume: 449, P: 346-350

  • These authors describe a molecular pathway by which endothelial cells sustain liver regeneration after surgical resection. Activation of vascular endothelial growth factor-A receptor-2 in a defined subpopulation of liver endothelial cells leads to the upregulation of the endothelial-specific transcription factor Id1, which in turn induces Wnt2 and hepatocyte growth factor, which are secreted from the endothelial cells and trigger hepatocyte proliferation.

    • Bi-Sen Ding
    • Daniel J. Nolan
    • Shahin Rafii
    Research
    Nature
    Volume: 468, P: 310-315

  • Phenotypic diversity of theca cells in growing follicles of the human ovary is described, with a differentiation trajectory proposed that initiates after follicle activation and results in multiple theca-cell subpopulations in antral follicles.

    • Nicole Lustgarten Guahmich
    • Limor Man
    • Daylon James
    ResearchOpen Access
    Communications Biology
    Volume: 6, P: 1-15