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Showing 1–12 of 12 results
Advanced filters: Author: Debbie Payne-Turner Clear advanced filters

  • A genomic and transcriptomic analysis of 2,754 childhood acute lymphoblastic leukemias identifies 376 putative driver genes, and associations between disease subtypes and prognosis.

    • Samuel W. Brady
    • Kathryn G. Roberts
    • Charles G. Mullighan
    Research
    Nature Genetics
    Volume: 54, P: 1376-1389

  • Analysis of genomic and clinical features of acute erythroid leukemia in comparison to other myeloid disorders supports its distinct classification, defines subgroups and suggests therapeutic vulnerabilities.

    • Ilaria Iacobucci
    • Ji Wen
    • Charles G. Mullighan
    Research
    Nature Genetics
    Volume: 51, P: 694-704

  • A large-scale genomics study shows that the cell of origin and founding mutations determine disease subtype and lead to the expression of multiple haematopoietic lineage-defining antigens in mixed phenotype acute leukaemia.

    • Thomas B. Alexander
    • Zhaohui Gu
    • Charles G. Mullighan
    Research
    Nature
    Volume: 562, P: 373-379

  • Acute lymphoblastic leukaemia is characterized by chromosomal rearrangements. Here, the authors carry out RNA-sequencing on a large cohort of patients and identify recurrent rearrangements of MEF2D, which lead to increased transcriptional activity of the gene, and cellular transformation in vitro.

    • Zhaohui Gu
    • Michelle Churchman
    • Charles G. Mullighan
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10

  • Analysis of 1,988 cases of B-cell acute lymphoblastic leukemia characterizes 23 subtypes defined by genomic features and shows that two of the subtypes have frequent PAX5 alterations.

    • Zhaohui Gu
    • Michelle L. Churchman
    • Charles G. Mullighan
    Research
    Nature Genetics
    Volume: 51, P: 296-307

  • Charles Mullighan, Jinghui Zhang and colleagues characterize a subtype of B-progenitor acute lymphoblastic leukemia with deregulated DUX4 and ERG. They find that aberrant DUX4 activation results in loss of ERG function, either through deletion or by the induction a novel transforming ERG isoform, ERGalt, that inhibits wild-type ERG activity.

    • Jinghui Zhang
    • Kelly McCastlain
    • Charles G Mullighan
    Research
    Nature Genetics
    Volume: 48, P: 1481-1489

  • Anna Andersson, Tanja Gruber, James Downing and colleagues report a genomic analysis of infant acute lymphoblastic leukemias with MLL rearrangements. They identify recurrent activating mutations in tyrosine kinase, phosphatidylinositol 3-kinase and RAS pathway genes but find that these mutations were often present in minor subclones and lost at the time of relapse.

    • Anna K Andersson
    • Jing Ma
    • James R Downing
    Research
    Nature Genetics
    Volume: 47, P: 330-337

  • In three different subtypes of B-cell lymphomas, two papers now report frequent somatic mutations in CREBBP and EP300, present in primary tumours or acquired at relapse. These genes encode related acetyltransferases that mainly function to regulate gene expression by acetylating histones and other transcriptional regulators. The mutations found inactivate these activities and thus alter chromatin regulation of gene expression, as well as proliferation and potentially the response to therapeutic drugs.

    • Charles G. Mullighan
    • Jinghui Zhang
    • James R. Downing
    Research
    Nature
    Volume: 471, P: 235-239