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Showing 1–4 of 4 results

Advanced filters: Author: Deepanwita Sengupta Clear advanced filters

Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases

Cryo-electron microscopy structures of the nucleosome-bound NSD2 and NSD3 histone methyltransferases reveal the molecular basis of their histone modification activity, and show how mutations in these proteins can lead to oncogenesis.

Wanqiu Li
Wei Tian
Zhanxin Wang
Research23 Dec 2020
Nature

Volume: 590, P: 498-503
Elevated NSD3 histone methylation activity drives squamous cell lung cancer

The histone H3K36 methyltransferase NSD3, which is associated with the common 8p11–12 chromosomal amplification, is an oncogenic driver in lung squamous cell carcinoma.

Gang Yuan
Natasha M. Flores
Or Gozani
Research03 Feb 2021
Nature

Volume: 590, P: 504-508
Loss-of-function and missense variants in NSD2 cause decreased methylation activity and are associated with a distinct developmental phenotype

Paolo Zanoni
Katharina Steindl
Anita Rauch
ResearchOpen Access03 May 2021
Genetics in Medicine

Volume: 23, P: 1474-1483
Indicators of responsiveness to immune checkpoint inhibitors

Bradley D. Shields
Fade Mahmoud
Alan J. Tackett
ResearchOpen Access11 Apr 2017
Scientific Reports

Volume: 7, P: 1-12