Follicular regulatory T (Tfr) cells modulate germinal center T and B cell responses, but how Tfr may control allograft rejection is still unclear. Here the authors show, using mouse kidney allograft rejection models, that Tfr suppresses the production of pro-inflammatory cytokines and alloreactive antibodies from alloreactive B cells to dampen graft rejection
- Hengcheng Zhang
- Manuel A. PodestÃ
- Peter T. Sage