Nature Search

Author Correction: Africa-specific human genetic variation near CHD1L associates with HIV-1 load

Paul J. McLaren
Immacolata Porreca
Jacques Fellay
Amendments and Corrections05 Sept 2023
Nature

Volume: 621, P: E42
Author Correction: Genomics of disease risk in globally diverse populations

Deepti Gurdasani
Inês Barroso
Manjinder S. Sandhu
Amendments and Corrections03 Jul 2019
Nature Reviews Genetics

Volume: 20, P: 562
Africa-specific human genetic variation near CHD1L associates with HIV-1 load

Africa-specific genetic variation on chromosome 1 near CHD1L is associated with HIV replication in vivo.

Paul J. McLaren
Immacolata Porreca
Jacques Fellay
Research02 Aug 2023
Nature

Volume: 620, P: 1025-1030
The African Genome Variation Project shapes medical genetics in Africa

The African Genome Variation Project contains the whole-genome sequences of 320 individuals and dense genotypes on 1,481 individuals from sub-Saharan Africa; it enables the design and interpretation of genomic studies, with implications for finding disease loci and clues to human origins.

Deepti Gurdasani
Tommy Carstensen
Manjinder S. Sandhu
ResearchOpen Access03 Dec 2014
Nature

Volume: 517, P: 327-332
High-resolution African HLA resource uncovers HLA-DRB1 expression effects underlying vaccine response

Genome-wide analyses of vaccine antibody responses in 2,499 infants from Uganda, South Africa and Burkina Faso identify associations between specific HLA genes and response to eight vaccines, providing insights that could be considered for population-adjusted vaccine design strategies.

Alexander J. Mentzer
Alexander T. Dilthey
Manjinder S. Sandhu
ResearchOpen Access13 May 2024
Nature Medicine

Volume: 30, P: 1384-1394
Distinct genetic architectures and environmental factors associate with host response to the γ2-herpesvirus infections

Disease prognosis after infection with Kaposi’s sarcoma-associated herpesvirus and Epstein-Barr Virus is highly variable. Here the authors carry out epidemiological and genetic analysis of a Ugandan cohort and suggest complex interactions may influence pathogenesis and transmission.

Neneh Sallah
Wendell Miley
Inês Barroso
ResearchOpen Access31 Jul 2020
Nature Communications

Volume: 11, P: 1-13
The transferability of lipid loci across African, Asian and European cohorts

The majority of published GWAS was performed in European ancestry populations. Here, Kuchenbaecker et al., test to which extent lipid loci are shared and find that the major lipid loci are mostly transferrable between Europeans and Asians while there are notable exceptions for African populations.

Karoline Kuchenbaecker
Nikita Telkar
Dieter Wolke
ResearchOpen Access24 Sept 2019
Nature Communications

Volume: 10, P: 1-10
Machine learning to guide the use of adjuvant therapies for breast cancer

Methods are available to support clinical decisions regarding adjuvant therapies in breast cancer, but they have limitations in accuracy, generalizability and interpretability. Alaa et al. present an automated machine learning model of breast cancer that predicts patient survival and adjuvant treatment benefit to guide personalized therapeutic decisions.

Ahmed M. Alaa
Deepti Gurdasani
Mihaela van der Schaar
Research24 Jun 2021
Nature Machine Intelligence

Volume: 3, P: 716-726
Common variants associated with plasma triglycerides and risk for coronary artery disease

Sekar Kathiresan and colleagues examine 185 common variants using a modified mendelian randomization approach and provide evidence supporting a causal role of triglyceride-rich lipoproteins in the development of coronary artery disease.

Ron Do
Cristen J Willer
Sekar Kathiresan
Research06 Oct 2013
Nature Genetics

Volume: 45, P: 1345-1352
Discovery and refinement of loci associated with lipid levels

Cristen Willer and colleagues report genome-wide association analyses for blood lipid levels in 188,578 individuals. They identify 62 loci newly associated with blood lipid levels, refine the association signals at 12 loci and examine associations with cardiovascular and metabolic traits.

Cristen J Willer
Ellen M Schmidt
Gonçalo R Abecasis
Research06 Oct 2013
Nature Genetics

Volume: 45, P: 1274-1283
Genomics of disease risk in globally diverse populations

Global genomic diversity can provide new opportunities for discovery and translation into therapies, as well as a better understanding of population disease risks. This Review considers the value of examining diverse populations to better understand genetic contributors to disease risk and trait variation.

Deepti Gurdasani
Inês Barroso
Manjinder S. Sandhu
Reviews24 Jun 2019
Nature Reviews Genetics

Volume: 20, P: 520-535
Insights into the genetic architecture of haematological traits from deep phenotyping and whole-genome sequencing for two Mediterranean isolated populations

Karoline Kuchenbaecker
Arthur Gilly
Eleftheria Zeggini
ResearchOpen Access21 Jan 2022
Scientific Reports

Volume: 12, P: 1-13

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Author Correction: Africa-specific human genetic variation near CHD1L associates with HIV-1 load

Author Correction: Genomics of disease risk in globally diverse populations

Africa-specific human genetic variation near CHD1L associates with HIV-1 load

The African Genome Variation Project shapes medical genetics in Africa

High-resolution African HLA resource uncovers HLA-DRB1 expression effects underlying vaccine response

Distinct genetic architectures and environmental factors associate with host response to the γ2-herpesvirus infections

The transferability of lipid loci across African, Asian and European cohorts

Machine learning to guide the use of adjuvant therapies for breast cancer

Common variants associated with plasma triglycerides and risk for coronary artery disease

Discovery and refinement of loci associated with lipid levels

Genomics of disease risk in globally diverse populations

Insights into the genetic architecture of haematological traits from deep phenotyping and whole-genome sequencing for two Mediterranean isolated populations

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