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Showing 1–2 of 2 results
Advanced filters: Author: Dena Almeida Clear advanced filters

  • Proliferative vitreoretinopathy (PVR) is a vision-threatening response to ocular injury, in which retinal cells secrete tractional, scar-forming proteins. Here, the authors show that antibody blockade of either Annexin A2 or its inducer, macrophage inflammatory protein-1, prevents PVR in mice.

    • Min Luo
    • Dena Almeida
    • Katherine A. Hajjar
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Bissell, Ghajar and colleagues use organotypic culture systems and in vivo mouse and zebrafish models to reveal the distinct effects of different microvascular niches on tumour cell dormancy. They report that although the stable microvasculature promotes cancer cell quiescence through the production of thrombospondin-1, cancer cells residing near neovascular tips are induced to grow through the action of TGF-β and periostin.

    • Cyrus M. Ghajar
    • Héctor Peinado
    • Mina J. Bissell
    Research
    Nature Cell Biology
    Volume: 15, P: 807-817