Nature Search

A TGF-β pathway associated with cancer cachexia

Cancer cachexia leads to involuntary weight loss resulting from the atrophy of skeletal muscle and adipose tissues. Now, in metastatic mouse models of cancer, investigators reveal a cross talk pathway between bone and muscle that provides a new understanding of wasting in advanced cancers.

Denis C Guttridge
News & Views05 Nov 2015
Nature Medicine

Volume: 21, P: 1248-1249
Vascular collapse leads to muscle wasting in cancer cachexia

Muscle atrophy in cachexia drives weight loss and represents a major complication for patients with cancer. The tumor-derived cytokine activin A is now shown to decrease endothelial cell viability in skeletal muscle, leading to loss of muscle mass and function and inducing cachexia in multiple preclinical cancer models.

Denis C. Guttridge
Teresa A. Zimmers
News & Views27 Jun 2025
Nature Cancer

Volume: 6, P: 1301-1303
Selective activation of NF-κB subunits in human breast cancer: potential roles for NF-κB2/p52 and for Bcl-3

Patricia C Cogswell
Denis C Guttridge
Albert S Baldwin
Research07 Mar 2000
Oncogene

Volume: 19, P: 1123-1131
NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model

The molecular mechanisms leading to heart failure in patients with Duchenne muscular dystrophy are unclear. Here the authors show that NF-κB is activated in the heart of dystrophin-deficient mice and that its ablation rescues cardiac function through chromatin remodeling and activation of gene expression.

Jennifer M. Peterson
David J. Wang
Denis C. Guttridge
ResearchOpen Access24 Aug 2018
Nature Communications

Volume: 9, P: 1-14
Global spatial risk assessment of sharks under the footprint of fisheries

A global dataset of the satellite-tracked movements of pelagic sharks and fishing fleets show that sharks—and, in particular, commercially important species—have limited spatial refuge from fishing effort.

Nuno Queiroz
Nicolas E. Humphries
David W. Sims
Research24 Jul 2019
Nature

Volume: 572, P: 461-466
Expression of cancer-testis antigens MAGEA1, MAGEA3, ACRBP, PRAME, SSX2, and CTAG2 in myxoid and round cell liposarcoma

Jessica A Hemminger
Amanda Ewart Toland
O Hans Iwenofu
Research24 Jan 2014
Modern Pathology

Volume: 27, P: 1238-1245
The cancer-testis antigen NY-ESO-1 is highly expressed in myxoid and round cell subset of liposarcomas

Jessica A Hemminger
Amanda Ewart Toland
O Hans Iwenofu
Research31 Aug 2012
Modern Pathology

Volume: 26, P: 282-288
Cancer-associated cachexia

Cancer-associated cachexia is a disorder characterized by the loss of skeletal muscle and adipose tissue that is driven by reduced food intake and metabolic changes. In this Primer, Baracos et al. discuss emerging mechanistic insights and the approach to caring for vulnerable patients with cancer-associated cachexia.

Vickie E. Baracos
Lisa Martin
Kenneth C. H. Fearon
Reviews18 Jan 2018
Nature Reviews Disease Primers

Volume: 4, P: 1-18
A selective screening platform reveals unique global expression patterns of microRNAs in a cohort of human soft-tissue sarcomas

Peter Y Yu
Mumtaz Y Balkhi
O Hans Iwenofu
Research15 Feb 2016
Laboratory Investigation

Volume: 96, P: 481-491

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A TGF-β pathway associated with cancer cachexia

Vascular collapse leads to muscle wasting in cancer cachexia

Selective activation of NF-κB subunits in human breast cancer: potential roles for NF-κB2/p52 and for Bcl-3

NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model

Global spatial risk assessment of sharks under the footprint of fisheries

Expression of cancer-testis antigens MAGEA1, MAGEA3, ACRBP, PRAME, SSX2, and CTAG2 in myxoid and round cell liposarcoma

The cancer-testis antigen NY-ESO-1 is highly expressed in myxoid and round cell subset of liposarcomas

Cancer-associated cachexia

A selective screening platform reveals unique global expression patterns of microRNAs in a cohort of human soft-tissue sarcomas

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