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Showing 1–2 of 2 results
Advanced filters: Author: Denis Lacabanne Clear advanced filters
  • Lacabanne and Orelle et al. investigate a multidrug ABC transporter BmrA mutant defective in the X-loop, which uncouples ATP hydrolysis from substrate translocation. This study suggests that stiffening of a defined set of amino-acid residues allows the pump to transport substrates properly.

    • Denis Lacabanne
    • Cédric Orelle
    • Anja Böckmann
    ResearchOpen Access
    Communications Biology
    Volume: 2, P: 1-9
  • DnaB helicases are motor proteins that couple ATP-hydrolysis to the movement of the protein along single-stranded DNA leading to a separation of double-stranded DNA at the replication fork. Here authors use solid-state NMR spectroscopy and reveal DnaB’s conformational responses to ATP hydrolysis and the resulting DNA loading and translocation.

    • Thomas Wiegand
    • Riccardo Cadalbert
    • Beat H. Meier
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11