Here, Denise Lackey and Jerrold Olefsky discuss the innate immune cells involved in secreting inflammatory factors during obesity. The role of innate immune cells in maintaining an anti-inflammatory and insulin-sensitive environment in the lean state is also reviewed. This Review also provides an overview of the mechanisms for regulating proinflammatory immune responses that could lead to future therapeutic opportunities to improve insulin sensitivity.
- Denise E. Lackey
- Jerrold M. Olefsky
