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Showing 1–21 of 21 results
Advanced filters: Author: Dennis E. Discher Clear advanced filters

  • A common cellular manifestation for diverse kidney diseases is dysregulated actin cytoskeleton in distinct cell types that include glomerular podocytes and tubular epithelial cells. Here, authors pharmacologically activate dynamin and this results in polymerization and crosslinking of actin filaments to establish the structural integrity of these cells, thus ameliorating disease phenotypes.

    • Kamalika Mukherjee
    • Changkyu Gu
    • Sanja Sever
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • Arrays of microposts of different heights generate substrates with different flexibility, on which cells can be grown.

    • Amnon Buxboim
    • Dennis E Discher
    News & Views
    Nature Methods
    Volume: 7, P: 695-697

  • Pliable gels of fibrin, a fibrous protein involved in blood clotting and linked to cancer, select cells with high in vivo aggressiveness and 'stemness' from a pool of cancer cells.

    • Jae-Won Shin
    • Dennis E. Discher
    News & Views
    Nature Materials
    Volume: 11, P: 662-663

  • Synthetic microcapsules with membrane-bound inner chambers in which chemical reactions can be isolated and controlled have been assembled, layer by layer. Could artificial cells be on the horizon?

    • Catherine Picart
    • Dennis E. Discher
    News & Views
    Nature
    Volume: 448, P: 879-880

  • Using a microfluidic device, tiny polymeric capsules have been made in which different compounds can be isolated in separate, membrane-bound compartments — a prerequisite for the development of artificial cell aggregates.

    • Takamasa Harada
    • Dennis E. Discher
    News & Views
    Nature
    Volume: 471, P: 172-173

  • Controlled domain formation in block copolymer mixtures or lipid bilayers could lead to more highly ordered assemblies and delivery of drugs. It is now shown that mesoscale domain formation within assembled mixtures of neutral and anionic polymer amphiphiles can be induced by the divalent cations calcium and copper.

    • David A. Christian
    • Aiwei Tian
    • Dennis E. Discher
    Research
    Nature Materials
    Volume: 8, P: 843-849

  • The structural integrity of a cell’s nucleus is maintained by a polymer network known as the nuclear lamina. A simple biophysical theory reveals two regimes by which this network can rupture, depending on the structure of the nuclear envelope.

    • Dan Deviri
    • Charlotte R. Pfeifer
    • Samuel A. Safran
    Research
    Nature Physics
    Volume: 15, P: 823-829

  • Biological cells respond actively to the physical properties of their surroundings as well as to external mechanical forces — a coupling that is captured in a model of a cell as a contractile dipole, and shown to drive cell re-orientation.

    • Florian Rehfeldt
    • Dennis E. Discher
    News & Views
    Nature Physics
    Volume: 3, P: 592-593

  • To form tissues, like cells must clump together. The striking resemblance between one cell aggregate in flies and a cluster of soap bubbles points to a crucial role for surface mechanics in biological pattern formation.

    • Paul A. Janmey
    • Dennis E Discher
    News & Views
    Nature
    Volume: 431, P: 635-636

  • Detailed imaging reveals the structure of a spherical ‘micelle’, self-assembled from cone-shaped molecules, and marks progress towards mimicking the natural assembly skills of biological systems.

    • Dennis E. Discher
    • Randall D. Kamien
    News & Views
    Nature
    Volume: 430, P: 519-520

  • The exploitation of natural particulates, such as pathogens and mammalian cells, for drug delivery applications is a rapidly emerging field. Here, Yoo and colleagues discuss recent advances in the design of drug carriers based on natural particulates, provide an overview of their current development status and highlight the various applications and limitations of each approach.

    • Jin-Wook Yoo
    • Darrell J. Irvine
    • Samir Mitragotri
    Reviews
    Nature Reviews Drug Discovery
    Volume: 10, P: 521-535

  • Materials-based control of stem cell fate is beginning to be rigorously combined with traditional soluble-factor approaches to better understand the cells' behaviour and maximize their potential for therapy.

    • P. C. Dave P. Dingal
    • Dennis E. Discher
    Comments & Opinion
    Nature Materials
    Volume: 13, P: 532-537