Nature Search

Neural control of micturition in humans: a working model

Neural control of micturition is a complex process, involving input from many different brain regions. In this Review, Derek Griffiths describes a simplified model of neural control of micturition that incorporates current knowledge, largely derived from functional brain imaging studies of humans and experimental animals. Consideration is also given to the effects of treatments of urinary urgency on neural control of micturition.

Derek Griffiths
Reviews01 Dec 2015
Nature Reviews Urology

Volume: 12, P: 695-705
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

COVID-19 can be associated with neurological complications. Here the authors show that markers of brain injury, but not immune markers, are elevated in the blood of patients with COVID-19 both early and months after SARS-CoV-2 infection, particularly in those with brain dysfunction or neurological diagnoses.

Benedict D. Michael
Cordelia Dunai
David K. Menon
ResearchOpen Access22 Dec 2023
Nature Communications

Volume: 14, P: 1-15
Genomic reconstruction of the SARS-CoV-2 epidemic in England

A study of the evolution of the SARS-CoV-2 virus in England between September 2020 and June 2021 finds that interventions capable of containing previous variants were insufficient to stop the more transmissible Alpha and Delta variants.

Harald S. Vöhringer
Theo Sanderson
Moritz Gerstung
ResearchOpen Access14 Oct 2021
Nature

Volume: 600, P: 506-511
Correction: Corrigendum: The zebrafish reference genome sequence and its relationship to the human genome

Kerstin Howe
Matthew D. Clark
Derek L. Stemple
Amendments and Corrections11 Dec 2013
Nature

Volume: 505, P: 248
The neural control of micturition

Fowler and colleagues review the pathways and neurotransmitters in the brain, the spinal cord and the peripheral nervous system that regulate the lower urinary tract, and discuss how disruption of the control of micturition leads to incontinence.

Clare J. Fowler
Derek Griffiths
William C. de Groat
Reviews01 Jun 2008
Nature Reviews Neuroscience

Volume: 9, P: 453-466
Genetic mechanisms of critical illness in COVID-19

A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

Erola Pairo-Castineira
Sara Clohisey
J. Kenneth Baillie
Research11 Dec 2020
Nature

Volume: 591, P: 92-98
T cell memory response to MPXV infection exhibits greater effector function and migratory potential compared to MVA-BN vaccination

T cell responses can be generated to either pathogen infection or from priming with a vaccine. Here the authors compare T cell generation, phenotype and single cell transcriptome of participants vaccinated with a mpox vaccine or infected with the virus showing that the virus induced T cells showed more effective function and phenotype.

Ji-Li Chen
Beibei Wang
Tao Dong
ResearchOpen Access10 May 2025
Nature Communications

Volume: 16, P: 1-17
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

Mark Daly and colleagues present results of a combined analysis of data from three recent genome-wide association studies for Crohn's disease, followed by replication in a large independent sample collection. Their results confirm 11 previously reported risk loci and provide genome-wide significant evidence for 21 new loci associated with the disease.

Jeffrey C Barrett
Sarah Hansoul
Mark J Daly
Research29 Jun 2008
Nature Genetics

Volume: 40, P: 955-962
Digest

Derek Richards
Reviews17 Jul 2000
Evidence-Based Dentistry

Volume: 2, P: 29-30
SARS-CoV-2 evolution during treatment of chronic infection

Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Research05 Feb 2021
Nature

Volume: 592, P: 277-282
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Research11 Mar 2021
Nature

Volume: 593, P: 136-141
Multicolour imaging of post-Golgi sorting and trafficking in live cells

Patrick Keller
Derek Toomre
Kai Simons
Research15 Jan 2001
Nature Cell Biology

Volume: 3, P: 140-149
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
The zebrafish reference genome sequence and its relationship to the human genome

A high-quality sequence assembly of the zebrafish genome reveals the largest gene set of any vertebrate and provides information on key genomic features, and comparison to the human reference genome shows that approximately 70% of human protein-coding genes have at least one clear zebrafish orthologue.

Kerstin Howe
Matthew D. Clark
Derek L. Stemple
ResearchOpen Access17 Apr 2013
Nature

Volume: 496, P: 498-503
Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis

In vitro models to study the role of host genetics in the response to chlamydial infection are limited. Here, Yeung et al. show that macrophages derived from human induced pluripotent stem cells (which can be genetically manipulated) support chlamydial infection and can be used for this purpose.

Amy T. Y. Yeung
Christine Hale
Robert E. W. Hancock
ResearchOpen Access25 Apr 2017
Nature Communications

Volume: 8, P: 1-12
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

A randomized trial in patients hospitalized with COVID-19 showed no benefit and potentially increased harm associated with the use of convalescent plasma, with subgroup analyses suggesting that the antibody profile in donor plasma is critical in determining clinical outcomes.

Philippe Bégin
Jeannie Callum
Donald M. Arnold
ResearchOpen Access09 Sept 2021
Nature Medicine

Volume: 27, P: 2012-2024
Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

Benedict D. Michael
Cordelia Dunai
David K. Menon
Amendments and CorrectionsOpen Access04 Apr 2024
Nature Communications

Volume: 15, P: 1
Evolution of genes and genomes on the Drosophila phylogeny

An international consortium reports the genomic sequence for ten Drosophila species, and compares them to two other previously published Drosophila species. These data are invaluable for drawing evolutionary conclusions across an entire phylogeny of species at once.

Andrew G. Clark
Michael B. Eisen
Iain MacCallum
Research08 Nov 2007
Nature

Volume: 450, P: 203-218
Publisher Correction: Genomic reconstruction of the SARS CoV-2 epidemic in England

Harald S. Vöhringer
Theo Sanderson
Moritz Gerstung
Amendments and CorrectionsOpen Access07 Jun 2022
Nature

Volume: 606, P: E18
Linking genotype to phenotype on beads: high throughput selection of peptides with biological function

Li-Chieh Huang
Xiaoyan Pan
Graham Ogg
ResearchOpen Access23 Oct 2013
Scientific Reports

Volume: 3, P: 1-9
Reply to: Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Research10 Jan 2022
Nature Medicine

Volume: 28, P: 53-58
Digest

Derek Richards
Reviews28 Jun 2004
Evidence-Based Dentistry

Volume: 5, P: 53-54
Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning

Sema Nickbakhsh
Joseph Hughes
Alison Smith-Palmer
ResearchOpen Access19 Jul 2022
Scientific Reports

Volume: 12, P: 1-17
Author Correction: Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Amendments and CorrectionsOpen Access12 Jan 2022
Nature Medicine

Volume: 28, P: 212
Hydrogen sulfide regulates hippocampal neuron excitability via S-sulfhydration of Kv2.1

Mark L. Dallas
Moza M. Al-Owais
Chris Peers
ResearchOpen Access14 Apr 2021
Scientific Reports

Volume: 11, P: 1-11
Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E24
Author Correction: SARS-CoV-2 evolution during treatment of chronic infection

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E23
Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Edward J Saunders
Tokhir Dadaev
Zsofia Kote-Jarai
ResearchOpen Access10 Mar 2016
British Journal of Cancer

Volume: 114, P: 945-952
Quantifying neutralising antibody responses against SARS-CoV-2 in dried blood spots (DBS) and paired sera

Kelly J. Roper
Jordan Thomas
Georgios Pollakis
ResearchOpen Access11 Sept 2023
Scientific Reports

Volume: 13, P: 1-12
Distinct clinical symptom patterns in patients hospitalised with COVID-19 in an analysis of 59,011 patients in the ISARIC-4C study

Jonathan E. Millar
Lucile Neyton
Peter Young
ResearchOpen Access27 Apr 2022
Scientific Reports

Volume: 12, P: 1-13
Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition

Christos Mikropoulos
Christina G Hutten Selkirk
Rosalind A Eeles
ResearchOpen Access04 Jan 2018
British Journal of Cancer

Volume: 118, P: 266-276

Search

Neural control of micturition in humans: a working model

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Mapping the human genetic architecture of COVID-19

Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

Genomic reconstruction of the SARS-CoV-2 epidemic in England

Correction: Corrigendum: The zebrafish reference genome sequence and its relationship to the human genome

The neural control of micturition

Genetic mechanisms of critical illness in COVID-19

T cell memory response to MPXV infection exhibits greater effector function and migratory potential compared to MVA-BN vaccination

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

Digest

SARS-CoV-2 evolution during treatment of chronic infection

Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Multicolour imaging of post-Golgi sorting and trafficking in live cells

Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

The zebrafish reference genome sequence and its relationship to the human genome

Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis

Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

Evolution of genes and genomes on the Drosophila phylogeny

Publisher Correction: Genomic reconstruction of the SARS CoV-2 epidemic in England

Linking genotype to phenotype on beads: high throughput selection of peptides with biological function

Reply to: Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19

Digest

Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning

Author Correction: Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Hydrogen sulfide regulates hippocampal neuron excitability via S-sulfhydration of Kv2.1

Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Author Correction: SARS-CoV-2 evolution during treatment of chronic infection

Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Quantifying neutralising antibody responses against SARS-CoV-2 in dried blood spots (DBS) and paired sera

Distinct clinical symptom patterns in patients hospitalised with COVID-19 in an analysis of 59,011 patients in the ISARIC-4C study

Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition

Search

Quick links

Search

Filter By:

Search

Quick links