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Showing 1–6 of 6 results
Advanced filters: Author: Devan C. Diwanji Clear advanced filters

  • Suryamohan, Diwanji, Stawiski et al. identify natural ACE2 variants that are predicted to alter virus–host interactions. They find that soluble ACE2 K26R and T92I variants are more effective in blocking the entry of SARS-CoV-2 S-protein pseudotyped virus, compared to wild-type ACE2. This study suggests that ACE2 variants may modulate the host susceptibility to SARS-CoV-2.

    • Kushal Suryamohan
    • Devan Diwanji
    • Somasekar Seshagiri
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-11

  • PEAK pseudokinases are emerging disease targets, which regulate cell migration and proliferation through protein scaffolding. Here, the authors present the cryo-EM structure of the PEAK3/14-3-3 complex and reveal how 14-3-3 modulates PEAK3 localization and protein-protein interactions.

    • Hayarpi Torosyan
    • Michael D. Paul
    • Kliment A. Verba
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • Native-like soluble HIV envelope (Env) trimers are potential vaccine immunogens, and elimination of furin-dependence could provide a DNA-based alternative. Here, Sarkar et al. show that a cleavage-independent Env construct recapitulates the architecture and glycosylation of the native cleaved trimer.

    • Anita Sarkar
    • Shridhar Bale
    • Ian A. Wilson
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • The crystal structure of V1/V2, the only unresolved portion of the HIV-1 gp120 envelope glycoprotein, is reported in complex with human antibody PG9 and reveals a paradigm of antibody recognition with implications for vaccine development.

    • Jason S. McLellan
    • Marie Pancera
    • Peter D. Kwong
    Research
    Nature
    Volume: 480, P: 336-343