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Showing 1–3 of 3 results
Advanced filters: Author: Devaraj Subramanian Clear advanced filters
  • Mixed responses to targeted therapy within a patient are a clinical challenge. Here the authors show that TP53 loss-of-function cooperates with whole genome doubling which increases chromosomal instability. This leads to greater cellular diversity and multiple routes of resistance, which in turn promotes mixed responses to treatment.

    • Sebastijan Hobor
    • Maise Al Bakir
    • Charles Swanton
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-21
  • A mechanism for phosphoinositide conversion at endosomes to enable exit from the endosomal system, suggesting that defective phosphoinositide conversion at endosomes underlies X-linked centronuclear myopathy.

    • Katharina Ketel
    • Michael Krauss
    • Volker Haucke
    Research
    Nature
    Volume: 529, P: 408-412