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Showing 1–4 of 4 results
Advanced filters: Author: Devin Strickland Clear advanced filters

  • Light-inducible dimerization tags are engineered to rapidly recruit proteins to precise points in living yeast and mammalian cells. The affinities and response time of the interactions are tunable, and the authors used the system to activate cell signaling and to direct cell polarization in yeast.

    • Devin Strickland
    • Yuan Lin
    • Michael Glotzer
    Research
    Nature Methods
    Volume: 9, P: 379-384

  • Light-sensitive LOV domains show much promise for engineering proteins with photoswitchable activity. The dynamic range of a LOV domain is now substantially improved by the introduction of beneficial mutations predicted by an analytical model of photoswitching. The approach should prove useful to improve the function of multiple LOV-based switches.

    • Devin Strickland
    • Xiaolan Yao
    • Tobin R Sosnick
    Research
    Nature Methods
    Volume: 7, P: 623-626