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Proliferation in the auditory receptor epithelium mediated by a cyclic AMP–dependent signaling pathway

Dhasakumar S. Navaratnam
Henry S. Su
J. Carl Oberholtzer
Research01 Oct 1996
Nature Medicine

Volume: 2, P: 1136-1139
Single particle cryo-EM structure of the outer hair cell motor protein prestin

Prestin, expressed in outer hair cell (OHC), belongs to the Slc26 transporter family and functions as a voltage-driven motor that drives OHC electromotility. Here, the authors report cryo-EM structure and characterization of gerbil prestin, with insights into its mechanism of action.

Carmen Butan
Qiang Song
Joseph Santos-Sacchi
ResearchOpen Access12 Jan 2022
Nature Communications

Volume: 13, P: 1-11
Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack

Fragile X mental retardation protein (FMRP) binds to RNA and interacts with other ribonucleoproteins. Here, the authors describe both an interaction between FMRP and the sodium-activated potassium channel Slack-B and the FMRP regulation of Slack channel kinetics.

Maile R Brown
Jack Kronengold
Leonard K Kaczmarek
Research30 May 2010
Nature Neuroscience

Volume: 13, P: 819-821
Efferent feedback controls bilateral auditory spontaneous activity

Spontaneous activity generated in the cochleae propagates into the central auditory system to promote circuit formation before hearing onset. Here, the authors reveal the important role of cholinergic efferent modulation in coordinating bilateral spontaneous activity and the emergence of functional responses.

Yixiang Wang
Maya Sanghvi
Michael Crair
ResearchOpen Access27 Apr 2021
Nature Communications

Volume: 12, P: 1-16
Prestin kinetics and corresponding frequency dependence augment during early development of the outer hair cell within the mouse organ of Corti

Jun-Ping Bai
Dhasakumar Navaratnam
Joseph Santos-Sacchi
ResearchOpen Access11 Nov 2019
Scientific Reports

Volume: 9, P: 1-9
Single-cell transcriptomic atlas reveals increased regeneration in diseased human inner ear balance organs

Loss of inner ear hair cells leads to permanent hearing loss and balance dysfunction. Whether human utricular cells regenerate is unknown. Here, the authors present a single-cell resource of utricular cells from organ donors and schwannoma patients and describe transcriptional changes during homeostasis and in response to damage.

Tian Wang
Angela H. Ling
Alan G. Cheng
ResearchOpen Access06 Jun 2024
Nature Communications

Volume: 15, P: 1-19
Author Correction: Prestin kinetics and corresponding frequency dependence augment during early development of the outer hair cell within the mouse organ of Corti

Jun-Ping Bai
Dhasakumar Navaratnam
Joseph Santos-Sacchi
Amendments and CorrectionsOpen Access27 Aug 2020
Scientific Reports

Volume: 10, P: 1-3
Current carried by the Slc26 family member prestin does not flow through the transporter pathway

Jun-Ping Bai
Iman Moeini-Naghani
Dhasakumar Navaratnam
ResearchOpen Access19 Apr 2017
Scientific Reports

Volume: 7, P: 1-13
State dependent effects on the frequency response of prestin’s real and imaginary components of nonlinear capacitance

Joseph Santos-Sacchi
Dhasakumar Navaratnam
Winston J. T. Tan
ResearchOpen Access09 Aug 2021
Scientific Reports

Volume: 11, P: 1-15

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