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Showing 1–3 of 3 results

Advanced filters: Author: Dhaval Varshney Clear advanced filters

SINE transcription by RNA polymerase III is suppressed by histone methylation but not by DNA methylation

Transcription of short interspersed nuclear elements (SINEs) allows retrotransposition that contributes to chromosomal instability. Here, the authors show that methylation of histones, rather than DNA, plays a dominant role in suppressing SINE expression.

Dhaval Varshney
Jana Vavrova-Anderson
Robert J. White
ResearchOpen Access23 Mar 2015
Nature Communications

Volume: 6, P: 1-12
The regulation and functions of DNA and RNA G-quadruplexes

G-quadruplexes (G4s) are structures formed in guanine-rich DNA or RNA, which are linked to transcription, translation, chromatin biology, genome instability and RNA modifications. Recent studies connect G4 formation with cancer-cell lethality and indicate that G4s could be therapeutic targets.

Dhaval Varshney
Jochen Spiegel
Shankar Balasubramanian
Reviews20 Apr 2020
Nature Reviews Molecular Cell Biology

Volume: 21, P: 459-474
RNA G-quadruplex structures control ribosomal protein production

Dhaval Varshney
Sergio Martinez Cuesta
Shankar Balasubramanian
ResearchOpen Access23 Nov 2021
Scientific Reports

Volume: 11, P: 1-11