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Showing 1–3 of 3 results
Advanced filters: Author: Dheerendra Gupta Clear advanced filters

  • The role of coagulation factor FXII in diabetic kidney disease (DKD) remains unknown. Here, the authors show that zymogen FXII induces kidney injury via receptor (uPAR)-mediated signaling by inducing oxidative DNA damage and senescence, identifying new potential therapeutic targets for DKD.

    • Ahmed Elwakiel
    • Dheerendra Gupta
    • Berend Isermann
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20

  • Persistent diabetic complications despite controlled blood glucose levels, known as hyperglycemic memory, remain a poorly understood phenomenon in diabetic kidney disease. Here the authors identify senescence-associated gene p21 as a regulator of hyperglycemic memory, the suppression of which improves hyperglycemic memory and renal function.

    • Moh’d Mohanad Al-Dabet
    • Khurrum Shahzad
    • Berend Isermann
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • Graft-vs.-host disease is a complication of allogenic hematopoietic stem cell transplantation, and is associated with endothelial dysfunction. Here the authors show that activated protein C signals via PAR2/PAR3 to expand Treg cells, mitigating the disease in mice.

    • Satish Ranjan
    • Alexander Goihl
    • Berend Isermann
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16