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RETRACTED ARTICLE:Endocrine disruptors induce perturbations in endoplasmic reticulum and mitochondria of human pluripotent stem cell derivatives

Harmful chemicals that disrupt the endocrine system and hormone regulation have been associated with obesity. Here the authors apply a human pluripotent stem cell-based platform to study the effects of such compounds on developing gut endocrine and neuroendocrine systems.

Uthra Rajamani
Andrew R. Gross
Dhruv Sareen
ResearchOpen Access09 Aug 2017
Nature Communications

Volume: 8, P: 1-15
Retraction Note: Endocrine disruptors induce perturbations in endoplasmic reticulum and mitochondria of human pluripotent stem cell derivatives

Uthra Rajamani
Andrew R. Gross
Dhruv Sareen
Amendments and CorrectionsOpen Access02 Feb 2019
Nature Communications

Volume: 10, P: 1
Stem cell biologists sure play a mean pinball

Mouse fibroblasts are reprogrammed to functional neurons by expression of a few transcription factors.

Dhruv Sareen
Clive N Svendsen
News & Views01 Apr 2010
Nature Biotechnology

Volume: 28, P: 333-335
Modeling ALS with motor neurons derived from human induced pluripotent stem cells

In this Review, a collaboration of leading experts in amyotrophic lateral sclerosis (ALS) research present the state of the field regarding the use patient-derived induced pluripotent stem cells to generate motor neurons in vitro. Motor neuron characterization, including transcriptomics, molecular markers, neuron function and electrophysiology, are discussed in the context of maturation and disease.

Samuel Sances
Lucie I Bruijn
Clive N Svendsen
Reviews29 Mar 2016
Nature Neuroscience

Volume: 19, P: 542-553
Disease related changes in ATAC-seq of iPSC-derived motor neuron lines from ALS patients and controls

Amyotrophic Lateral Sclerosis (ALS) is highly heritable but the mechanisms of sporadic ALS are not fully understood. In this study, the authors identify drivers of variation and disease-relevant changes in the epigenomic profile of iPSC-derived motor neuron lines generated from ALS patients and healthy controls as part of the Answer ALS program.

Stanislav Tsitkov
Kelsey Valentine
Ernest Fraenkel
ResearchOpen Access02 May 2024
Nature Communications

Volume: 15, P: 1-15
Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice

The Huntington's disease (HD) induced pluripotent stem cell (iPSC) consortium describe the combined use of differentiated patient-derived iPSCs and systems biology to discover underlying mechanisms in HD. They identify neurodevelopmental deficits in HD cells that can be corrected in cells and in vivo with a small molecule.

Ryan G Lim
Lisa L Salazar
Clive N Svendsen
Research20 Mar 2017
Nature Neuroscience

Volume: 20, P: 648-660
A framework for sharing of clinical and genetic data for precision medicine applications

A secure framework that harmonizes storage and querying of clinical and genetic data using blockchain technology was developed to support combined genotype–phenotype queries, improving transparency into how and when health information is used.

Ahmed Elhussein
Ulugbek Baymuradov
Gamze Gürsoy
ResearchOpen Access03 Sept 2024
Nature Medicine

Volume: 30, P: 3578-3589
Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines

Answer ALS is a resource of patient-derived iPS cell lines, multi-omic data derived from iPS neurons and longitudinal clinical and smartphone data from over 1,000 patients with ALS. This serves as a foundation to identify distinct disease subgroups.

Emily G. Baxi
Terri Thompson
Jeffrey D. Rothstein
ResearchOpen Access03 Feb 2022
Nature Neuroscience

Volume: 25, P: 226-237
TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A

Risk variants for ALS and FTD in the synaptic gene UNC13A increase the expression of an UNC13A cryptic exon in neurons with TDP-43 depletion.

Anna-Leigh Brown
Oscar G. Wilkins
Pietro Fratta
ResearchOpen Access23 Feb 2022
Nature

Volume: 603, P: 131-137
Identifying patterns in amyotrophic lateral sclerosis progression from sparse longitudinal data

A machine learning approach is presented to identify dominant patterns in disease progression in amyotrophic lateral sclerosis (ALS), Alzheimer’s disease and Parkinson’s disease. The nonlinearity of ALS progression has important clinical implications.

Divya Ramamoorthy
Kristen Severson
Ernest Fraenkel
ResearchOpen Access08 Sept 2022
Nature Computational Science

Volume: 2, P: 605-616
ALS disrupts spinal motor neuron maturation and aging pathways within gene co-expression networks

ALS patient iPSC-derived motor neurons aim to model disease phenotypes. The authors demonstrate that these cells transcriptomically resemble fetal rather than adult spinal motor neurons, and familial and sporadic forms of ALS disrupt gene networks and pathways associated with neuronal maturation and aging. These data provide a resource for further understanding how molecular changes in motor neurons lead to disease.

Ritchie Ho
Samuel Sances
Clive N Svendsen
Research18 Jul 2016
Nature Neuroscience

Volume: 19, P: 1256-1267
Author Correction: TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A

Anna-Leigh Brown
Oscar G. Wilkins
Pietro Fratta
Amendments and CorrectionsOpen Access18 Jun 2024
Nature

Volume: 631, P: E7
A Comparison of mRNA Sequencing with Random Primed and 3′-Directed Libraries

Yuguang Xiong
Magali Soumillon
Marc R. Birtwistle
ResearchOpen Access07 Nov 2017
Scientific Reports

Volume: 7, P: 1-12
Directed Differentiation of Human Induced Pluripotent Stem Cells into Fallopian Tube Epithelium

Nur Yucer
Marie Holzapfel
Clive N. Svendsen
ResearchOpen Access06 Sept 2017
Scientific Reports

Volume: 7, P: 1-9
Cell freezing protocol suitable for ATAC-Seq on motor neurons derived from human induced pluripotent stem cells

Pamela Milani
Renan Escalante-Chong
Ernest Fraenkel
ResearchOpen Access05 May 2016
Scientific Reports

Volume: 6, P: 1-10
Transcriptome and proteome characterization of surface ectoderm cells differentiated from human iPSCs

Ying Qu
Bo Zhou
Xiaojiang Cui
ResearchOpen Access23 Aug 2016
Scientific Reports

Volume: 6, P: 1-14
NeuroLINCS Proteomics: Defining human-derived iPSC proteomes and protein signatures of pluripotency

Andrea D. Matlock
Vineet Vaibhav
Jennifer E. Van Eyk
ResearchOpen Access11 Jan 2023
Scientific Data

Volume: 10, P: 1-11

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