Nature Search

Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance

Polθ has been recently identified as a therapeutic target in cancer but specific inhibitors are currently unavailable. Here, the authors identify small molecule inhibitors of Polθ’s polymerase activity which elicit BRCA1/2 synthetic lethality, enhance the effect of PARP inhibitors and target PARP inhibitor resistance caused by 53BP1/Shieldin pathway defects.

Diana Zatreanu
Helen M. R. Robinson
Christopher J. Lord
ResearchOpen Access17 Jun 2021
Nature Communications

Volume: 12, P: 1-15
Chemically-inducible CRISPR/Cas9 circuits for ultra-high dynamic range gene perturbation

Achieving tight Cas9 regulation without sacrificing activity remains difficult. Here, the authors design multi-level circuits combining anti-CRISPRs, splice sites, chemical induction, and degron control to enable ultra-high dynamic range and precise, on-demand genome editing across contexts.

Rajini Srinivasan
Tao Sun
Benjamin Haley
ResearchOpen Access12 Dec 2025
Nature Communications

Volume: 17, P: 1-16
Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists

Stapled α-helical peptides are promising for targeting challenging targets such as transcription factors, but achieving sufficient cell permeability while avoiding off-target cleavage is difficult. Here, the authors present workflows for identifying stapled peptides against Mdm2(X) with in vivo activity and no off-target effects based on comprehensive investigations of their properties.

Arun Chandramohan
Hubert Josien
Anthony W. Partridge
ResearchOpen Access12 Jan 2024
Nature Communications

Volume: 15, P: 1-19
PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma

Mutations in the Protein Phosphatase PPM1D are oncogenic in certain cancers including diffuse intrinsic pontine glioma (DIPG). Here, the authors show that PPM1D mutations in DIPG induce the silencing of the nicotinic acid phosphoribosyltransferase gene and display synthetic lethality with nicotinamide phosphoribosyltransferase inhibitors.

Nathan R. Fons
Ranjini K. Sundaram
Ranjit S. Bindra
ResearchOpen Access22 Aug 2019
Nature Communications

Volume: 10, P: 1-10
Combined inhibition of NAD synthesis and C-terminal binding protein cooperatively induces cell death and inhibits growth of high grade serous ovarian carcinoma

Kranthi Kumar Chougoni
Jacqueline West
Steven R. Grossman
ResearchOpen Access06 Dec 2025
Scientific Reports

Volume: 16, P: 1-9
Feasibility of functional precision medicine for guiding treatment of relapsed or refractory pediatric cancers

In an observational study evaluating functional precision medicine in children and adolescents with relapsed or refractory solid and hematologic malignancies, it was feasible to provide personalized treatment recommendations to treating physicians on the basis of genomic profiling and ex vivo drug sensitivity testing within 4 weeks.

Arlet M. Acanda De La Rocha
Noah E. Berlow
Diana J. Azzam
ResearchOpen Access11 Apr 2024
Nature Medicine

Volume: 30, P: 990-1000
Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism

A comprehensive analysis of models of brain metastasis and multiple cohorts of patient samples identifies a targetable molecular mechanism underlying the resistance to whole-brain radiotherapy that can inform patient selection for personalized radiotherapy.

Cátia Monteiro
Lauritz Miarka
Manuel Valiente
ResearchOpen Access11 Apr 2022
Nature Medicine

Volume: 28, P: 752-765
Self-dialogue with age-congruent versus age-incongruent avatars in immersive virtual reality

Diana C. G. Mendes
Ana Fonseca
Mónica S. Cameirão
ResearchOpen Access30 Oct 2025
Scientific Reports

Volume: 15, P: 1-13
A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models

van Lengerich et al. developed a human TREM2 antibody with a transport vehicle (ATV) that improves brain exposure and biodistribution in mouse models. ATV:TREM2 promotes microglial energetic capacity and metabolism via mitochondrial pathways.

Bettina van Lengerich
Lihong Zhan
Kathryn M. Monroe
ResearchOpen Access12 Jan 2023
Nature Neuroscience

Volume: 26, P: 416-429
Regulation of autoantibody activity by the IL-23–T_H17 axis determines the onset of autoimmune disease

Krönke and colleagues show that the cytokine IL-23 controls the glycosylation profile and inflammatory activity of autoantibodies through control of sialyltransferase activity in plasma cells mediated by the T_H17 subset of helper T cells.

René Pfeifle
Tobias Rothe
Gerhard Krönke
Research07 Nov 2016
Nature Immunology

Volume: 18, P: 104-113
Blueprint for a pop-up SARS-CoV-2 testing lab

Alexandra M. Amen
Kerrie W. Barry
Lea B. Witkowsky
Correspondence18 Jun 2020
Nature Biotechnology

Volume: 38, P: 791-797
Downregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children

Multisystem inflammatory syndrome in children (MIS-C) onsets in COVID-19 patients with manifestations similar to Kawasaki disease (KD). Here the author probe the peripheral blood transcriptome of MIS-C patients to find signatures related to natural killer (NK) cell activation and CD8+ T cell exhaustion that are shared with KD patients.

Noam D. Beckmann
Phillip H. Comella
Alexander W. Charney
ResearchOpen Access11 Aug 2021
Nature Communications

Volume: 12, P: 1-15
Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance

Although the asymmetric dimethylation of histone H3R2 acts as a repressive mark, new studies reveal that symmetrically dimethylated H3R2 (H3R2me2s) is a functional histone mark in vivo. The RBBP7 co-repressor is excluded from binding H3R2me2s in favor of the coactivator WDR5, which poises euchromatic genes for transcription activation upon cell-cycle exit and differentiation.

Valentina Migliori
Julius Müller
Ernesto Guccione
Research08 Jan 2012
Nature Structural & Molecular Biology

Volume: 19, P: 136-144
Optimal Gestational Age for Twin Delivery

Izuka Udom-Rice
Steven R Inglis
Frank A Chervenak
Research29 Jun 2000
Journal of Perinatology

Volume: 20, P: 231-234
Author Correction: Sampling the host response to SARS-CoV-2 in hospitals under siege

Alexander W. Charney
Nicole W. Simons
Miriam Merad
Amendments and Corrections05 Feb 2021
Nature Medicine

Volume: 27, P: 560
Molecular states during acute COVID-19 reveal distinct etiologies of long-term sequelae

Transcriptomic analyses of acute phase whole blood from a large cohort of patients with COVID-19 identify molecular determinants of post-infection long-term sequelae.

Ryan C. Thompson
Nicole W. Simons
Noam D. Beckmann
ResearchOpen Access08 Dec 2022
Nature Medicine

Volume: 29, P: 236-246
Author Correction: Sampling the host response to SARS-CoV-2 in hospitals under siege

Alexander W. Charney
Nicole W. Simons
Miriam Merad
Amendments and Corrections21 Aug 2020
Nature Medicine

Volume: 26, P: 1493
Sampling the host response to SARS-CoV-2 in hospitals under siege

Alexander W. Charney
Nicole W. Simons
Miriam Merad
Correspondence27 Jul 2020
Nature Medicine

Volume: 26, P: 1157-1158
Identification of novel small molecule-based strategies of COL7A1 upregulation and readthrough activity for the treatment of recessive dystrophic epidermolysis bullosa

Irene Jover
Maria C. Ramos
Arsenio Nueda
ResearchOpen Access16 Aug 2024
Scientific Reports

Volume: 14, P: 1-21
Childhood overeating is associated with adverse cardiometabolic and inflammatory profiles in adolescence

Christopher Hübel
Moritz Herle
Nadia Micali
ResearchOpen Access14 Jun 2021
Scientific Reports

Volume: 11, P: 1-15
NQO1 protects obese mice through improvements in glucose and lipid metabolism

Andrea Di Francesco
Youngshim Choi
Rafael de Cabo
ResearchOpen Access19 Nov 2020
npj Aging and Mechanisms of Disease

Volume: 6, P: 1-18
Scribble co-operatively binds multiple α_1D-adrenergic receptor C-terminal PDZ ligands

Eric M. Janezic
Dorathy-Ann Harris
Chris Hague
ResearchOpen Access01 Oct 2019
Scientific Reports

Volume: 9, P: 1-11
Cellular manganese content is developmentally regulated in human dopaminergic neurons

Kevin K. Kumar
Edward W. Lowe, Jr.
Aaron B. Bowman
ResearchOpen Access28 Oct 2014
Scientific Reports

Volume: 4, P: 1-8
Further delineation of the KAT6B molecular and phenotypic spectrum

Tamsin Gannon
Rahat Perveen
Jill Clayton-Smith
Research26 Nov 2014
European Journal of Human Genetics

Volume: 23, P: 1165-1170
Single-cell template strand sequencing by Strand-seq enables the characterization of individual homologs

Strand-seq is a single-cell template strand sequencing technology that generates directional genomic libraries, which allows the characterization of individual homologs.

Ashley D Sanders
Ester Falconer
Peter M Lansdorp
Protocols11 May 2017
Nature Protocols

Volume: 12, P: 1151-1176
PPP2R1A mutations cause ATR inhibitor sensitivity in ovarian clear cell carcinoma

James Stewart
Dragomir B. Krastev
Christopher J. Lord
ResearchOpen Access12 Feb 2025
Oncogene

Volume: 44, P: 618-629

Search

Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance

Chemically-inducible CRISPR/Cas9 circuits for ultra-high dynamic range gene perturbation

Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists

PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma

Combined inhibition of NAD synthesis and C-terminal binding protein cooperatively induces cell death and inhibits growth of high grade serous ovarian carcinoma

Feasibility of functional precision medicine for guiding treatment of relapsed or refractory pediatric cancers

Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism

Self-dialogue with age-congruent versus age-incongruent avatars in immersive virtual reality

A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models

Regulation of autoantibody activity by the IL-23–T_H17 axis determines the onset of autoimmune disease

Blueprint for a pop-up SARS-CoV-2 testing lab

Downregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children

Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance

Optimal Gestational Age for Twin Delivery

Author Correction: Sampling the host response to SARS-CoV-2 in hospitals under siege

Molecular states during acute COVID-19 reveal distinct etiologies of long-term sequelae

Author Correction: Sampling the host response to SARS-CoV-2 in hospitals under siege

Sampling the host response to SARS-CoV-2 in hospitals under siege

Identification of novel small molecule-based strategies of COL7A1 upregulation and readthrough activity for the treatment of recessive dystrophic epidermolysis bullosa

Childhood overeating is associated with adverse cardiometabolic and inflammatory profiles in adolescence

NQO1 protects obese mice through improvements in glucose and lipid metabolism

Scribble co-operatively binds multiple α_1D-adrenergic receptor C-terminal PDZ ligands

Cellular manganese content is developmentally regulated in human dopaminergic neurons

Further delineation of the KAT6B molecular and phenotypic spectrum

Single-cell template strand sequencing by Strand-seq enables the characterization of individual homologs

PPP2R1A mutations cause ATR inhibitor sensitivity in ovarian clear cell carcinoma

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