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Non-AUG HIV-1 uORF translation elicits specific T cell immune response and regulates viral transcript expression

Here, integrating ribosome profiling, RNA-seq and proteomics to reveal transcriptional and post-translational regulation in HIV-infected T cells, the authors show that non-AUG translation of viral upstream ORFs elicits distinct immune responses and regulates viral gene expression in a DDX3-dependent manner.

Emmanuel Labaronne
Didier Décimo
Emiliano P. Ricci
ResearchOpen Access18 Feb 2025
Nature Communications

Volume: 16, P: 1-22
Author Correction: Unveiling conserved HIV-1 open reading frames encoding T cell antigens using ribosome profiling

Lisa Bertrand
Annika Nelde
Arnaud Moris
Amendments and CorrectionsOpen Access06 Mar 2025
Nature Communications

Volume: 16, P: 1
Unveiling conserved HIV-1 open reading frames encoding T cell antigens using ribosome profiling

Here, using ribosomal profiling, the authors characterize the translatome of HIV-1 revealing tens of alternative open reading frames (ARF) that encode conserved viral antigens and show that ARF-derived peptides elicit potent HIV-specific poly-functional immune responses mediated by both CD4⁺ and CD8⁺ T cells.

Lisa Bertrand
Annika Nelde
Arnaud Moris
ResearchOpen Access18 Feb 2025
Nature Communications

Volume: 16, P: 1-18
Hamster organotypic modeling of SARS-CoV-2 lung and brainstem infection

Here, Ferren et al. isolate Syrian hamster brainstem and lung tissue to establish ex vivo culture systems to study SARS-CoV-2 local viral tropism, immune response and tissue pathology. Further, they provide evidence that these systems can be used for screening of anti-viral compounds.

Marion Ferren
Valérie Favède
Cyrille Mathieu
ResearchOpen Access04 Oct 2021
Nature Communications

Volume: 12, P: 1-17
HIV-2 genomic RNA contains a novel type of IRES located downstream of its initiation codon

Cécile H Herbreteau
Laure Weill
Théophile Ohlmann
Research23 Oct 2005
Nature Structural & Molecular Biology

Volume: 12, P: 1001-1007
Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum

Farber and colleagues report distinct antibody responses to SARS-CoV-2 in pediatric cohorts, including those who developed multisystem inflammatory syndrome (MIS-C), and adult COVID-19 cohorts.

Stuart P. Weisberg
Thomas J. Connors
Donna L. Farber
Research05 Nov 2020
Nature Immunology

Volume: 22, P: 25-31
Intranasally administrated fusion-inhibitory lipopeptides block SARS-CoV-2 infection in mice and enable long-term protective immunity

Intranasally administrated fusion-inhibitory lipopeptides derived from the SARS-CoV-2 spike protect mice from different viral variants and induce cross-reactive immunity, offering a innovative antiviral approach against COVID-19

Said Mougari
Valérie Favède
Branka Horvat
ResearchOpen Access15 Jan 2025
Communications Biology

Volume: 8, P: 1-16

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Non-AUG HIV-1 uORF translation elicits specific T cell immune response and regulates viral transcript expression

Author Correction: Unveiling conserved HIV-1 open reading frames encoding T cell antigens using ribosome profiling

Unveiling conserved HIV-1 open reading frames encoding T cell antigens using ribosome profiling

Hamster organotypic modeling of SARS-CoV-2 lung and brainstem infection

HIV-2 genomic RNA contains a novel type of IRES located downstream of its initiation codon

Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum

Intranasally administrated fusion-inhibitory lipopeptides block SARS-CoV-2 infection in mice and enable long-term protective immunity

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