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Showing 1–2 of 2 results
Advanced filters: Author: Dikla Ben-Shushan Clear advanced filters

  • Glioma-associated microglia/macrophages are central drivers of brain tumor pathology. Here the authors characterize the role of the P-selectin/PSGL-1 axis in the cross-talk between glioblastoma cells and microglia/macrophages and show that the therapeutic targeting of P-selectin limits glioblastoma progression in preclinical models.

    • Eilam Yeini
    • Paula Ofek
    • Ronit Satchi-Fainaro
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-22

  • Treatment of pancreatic ductal adenocarcinoma is still challenging and patients survival has only marginally improved in the last decade. Here the authors produce a PGA-based polymeric nanocarrier for the dual delivery of miR-34a-mimic and PLK1-targeting siRNA resulting in killing of pancreatic cancer cells in vivo.

    • Hadas Gibori
    • Shay Eliyahu
    • Ronit Satchi-Fainaro
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-18