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Showing 1–5 of 5 results
Advanced filters: Author: Dimitrios Davalos Clear advanced filters
  • Multiple sclerosis is characterized by the activation of microglia cells. Davalos et al. investigate the early stages of neuroinflammation in mice and reveal that the plasma protein fibrinogen induces microglial clustering around the brain vasculature, which facilitates lesion formation and focal axonal damage.

    • Dimitrios Davalos
    • Jae Kyu Ryu
    • Katerina Akassoglou
    ResearchOpen Access
    Nature Communications
    Volume: 3, P: 1-15
  • A systematic analysis of 115 mammalian genomes, including 10 new bat genomes, reveals prevalent positive selection in immune genes in bats and shows key adaptations in the antiviral gene ISG15 that aid disease resistance in bats, including to coronaviruses.

    • Ariadna E. Morales
    • Yue Dong
    • Michael Hiller
    ResearchOpen Access
    Nature
    Volume: 638, P: 449-458
  • A polished and reinforced thinned-skull procedure is used to create a large, chronically stable window in the skull that allows repeated imaging of cortical structures as well as optically guided physiological manipulation. It is proposed as an alternative to the craniotomy and current thinned-skull methods.

    • Patrick J Drew
    • Andy Y Shih
    • David Kleinfeld
    Research
    Nature Methods
    Volume: 7, P: 981-984
  • Fibrin deposition occurs after the blood–brain barrier is breached. Akassoglou and colleagues generate a therapeutic monoclonal antibody that targets a cryptic fibrin epitope to suppress activation of innate immune responses in the CNS and diminish neuroinflammation.

    • Jae Kyu Ryu
    • Victoria A. Rafalski
    • Katerina Akassoglou
    Research
    Nature Immunology
    Volume: 19, P: 1212-1223