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Advanced filters: Author: Dimitrios Mamalis Clear advanced filters

  • In this Tools of the Trade article, Yi and Mamalis (Gilbert and Davis labs) discuss the development of Di-Gembodies, innovative constructs designed to overcome key challenges in applying cryo-electron microscopy to small proteins that are otherwise difficult to resolve.

    • Gangshun Yi
    • Dimitrios Mamalis
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 27, P: 174

  • Disulfide-based dimerization of modified identical and heterologous nanobody scaffolds enables higher-order assembly for high-resolution cryo-electron microscopy structure determination that is widely applicable to small protein targets.

    • Gangshun Yi
    • Dimitrios Mamalis
    • Robert J. C. Gilbert
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 22, P: 69-76