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Advanced filters: Author: Dimitrios Michael Vitsios Clear advanced filters

Identification of plasma proteomic markers underlying polygenic risk of type 2 diabetes and related comorbidities

Here, the authors leveraged genetic and proteomic information from the UK Biobank and two randomized controlled trials to characterize how polygenic disease risk for T2D and related comorbidities perturbs the plasma proteome and glean therapeutic insights.

Douglas P. Loesch
Manik Garg
Michael Inouye
ResearchOpen Access03 Mar 2025
Nature Communications

Volume: 16, P: 1-16
Rare variant contribution to human disease in 281,104 UK Biobank exomes

The authors analyse rare protein-coding genetic variants for association with 18,780 traits in the UK Biobank cohort.

Quanli Wang
Ryan S. Dhindsa
Slavé Petrovski
ResearchOpen Access10 Aug 2021
Nature

Volume: 597, P: 527-532
A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis

Marcos Morgan
Yuka Kabayama
Dónal O’Carroll
ResearchOpen Access07 Jan 2019
Cell Research

Volume: 29, P: 221-232