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Head and neck tumor organoid grown under simplified media conditions model tumor biology and chemoradiation responses

Weilin Li
Michiya Nishino
Senthil K. Muthuswamy
ResearchOpen Access07 Jul 2025
Scientific Reports

Volume: 15, P: 1-13
Targeting the disordered C terminus of PTP1B with an allosteric inhibitor

The allosteric binding of MSI-1436 to the intrinsically disordered C-terminal region of PTP1B promotes a conformational change to generate a compact inactive structure, validating the use of MSI-1436 to inhibit HER2-mediated tumorigenesis.

Navasona Krishnan
Dorothy Koveal
Nicholas K Tonks
Research20 May 2014
Nature Chemical Biology

Volume: 10, P: 558-566

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Head and neck tumor organoid grown under simplified media conditions model tumor biology and chemoradiation responses

Targeting the disordered C terminus of PTP1B with an allosteric inhibitor

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